Research on bimodal contrast agents in general and optical/MRI contrast agents in
particular has attracted increased attention from the scientific community in recent years …

One of the early pathological hallmarks of Alzheimer׳ s disease (AD) is the deposition of
amyloid-β (Aβ) plaques in the brain. There has been a tremendous interest in the …

Non-invasive methods for the in vivo detection of hallmarks of Alzheimer's disease can
facilitate the study of the progression of the disease in mouse models and may enable its …

Given the known water exchange rate limitations of a previously reported Zn (II)-sensitive
MRI contrast agent, GdDOTA-diBPEN, new structural targets were rationally designed to …

Alzheimer's disease (AD) is currently an incurable neurodegenerative disorder that affects
millions of people around the world. The aggregation of amyloid-β peptides (Aβ), one of the …

Protein aggregation has been widely implicated in neurodegenerative diseases such as
Alzheimer's disease, frontotemporal dementia, Parkinson's disease, and Huntington …

Background Amyloidoses are characterized by the extracellular deposition of insoluble
fibrillar proteinaceous aggregates highly organized into cross-β structure and referred to as …

Alzheimer's disease (AD) is a neurodegenerative disorder characterised by brain
accumulation of toxic protein aggregates, including extracellular amyloid beta (Aβ) plaques …

A series of dual-functional red-emitting fluorescent probes were rationally designed,
synthesized and evaluated through the introduction of amine chains based on a neutral …

Noninvasive imaging of amyloid-β (Aβ) species in vivo is important for the early diagnosis of
Alzheimer's disease (AD). In this paper, we report a near-infrared (NIR) fluorescence (FL) …