The transcription factor p53 is an important regulator of a multitude of cellular processes. In
the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest …

The regulation of DNA excision repair pathways by p53 and its downstream genes is an
emerging body of literature, largely distinct and separable from the more-studied cell cycle …

DETA-NONOate, a nitric oxide (NO) donor, induced cytostasis in the human breast cancer
cells MDA-MB-231, and the cells were arrested in the G1 phase of the cell cycle. This …

Mutations in TP53 lead to a defective G1 checkpoint and the dependence on checkpoint
kinase 1 (Chk1) for G2 or S phase arrest in response to DNA damage. In preclinical studies …

Apoptosis, known as programmed cell death, is a conserved, gene-directed mechanism for
the elimination of unnecessary or unwanted cells from an organism. A retrospective look at …

Abstract Purpose UCN-01 (7-hydroxystaurosporine) is a multi-targeted protein kinase
inhibitor that exhibits synergistic activity with DNA-damaging agents in preclinical studies …

Upon activation of mitogenic signaling cascades, cells commit to entry into a series of
regulated steps allowing traverse of the cell cycle. Synthesis of DNA (genome duplication) …

Progesterone is an important regulator of growth and differentiation in breast tissues. In this
study, the effect of progesterone on cell differentiation was evaluated in the estrogen …

One of the few books to cover all aspects of cyclin-dependent kinases (CDKs), Inhibitors of
Cyclin-dependent Kinases as Anti-tumor Agents provides an overview of CDKs as molecular …

The discovery of novel anti-cancer drugs targeting anaplastic lymphoma kinase (ALK), an
oncogenic tyrosine kinase, raises the need for in vitro assays suitable for screening …