Issues in the determination of 'responders' and 'non‐responders' in physiological research

G Atkinson, P Williamson… - Experimental …, 2019 - Wiley Online Library
New Findings What is the topic for this review? We discuss the dichotomization of
continuous‐level physiological measurements into 'responders' and 'non‐responders' when …

Is it worth it to personalize the treatment of PTSD?–A variance-ratio meta-analysis and estimation of treatment effect heterogeneity in RCTs of PTSD

P Herzog, T Kaiser - Journal of Anxiety Disorders, 2022 - Elsevier
Several evidence-based treatments for posttraumatic stress disorder (PTSD) are
recommended by international guidelines (eg, APA, NICE). While their average effects are in …

Heterogeneity of treatment effects in trials on psychotherapy of depression.

T Kaiser, C Volkmann, A Volkmann… - … Science and Practice, 2022 - psycnet.apa.org
Practitioners and researchers alike assume that there is individual variability in the effects of
treatments for mental disorders. However, for psychotherapy, up to now this assumption has …

Revisiting and expanding the meta‐analysis of variation: The log coefficient of variation ratio

AM Senior, W Viechtbauer… - Research Synthesis …, 2020 - Wiley Online Library
Meta‐analyses are often used to estimate the relative average values of a quantitative
outcome in two groups (eg, control and experimental groups). However, they may also …

Methods and challenges for assessing heterogeneity

E Feczko, DA Fair - Biological psychiatry, 2020 - Elsevier
The widely acknowledged homogeneity assumption limits progress in refining clinical
diagnosis, understanding mechanisms, and developing new treatments for mental health …

Evaluation of differences in individual treatment response in schizophrenia spectrum disorders: a meta-analysis

S Winkelbeiner, S Leucht, JM Kane, P Homan - JAMA psychiatry, 2019 - jamanetwork.com
Importance An assumption among clinicians and researchers is that patients with
schizophrenia vary considerably in their response to antipsychotic drugs in randomized …

Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between trial arms

HL Mills, JPT Higgins, RW Morris, D Kessler… - …, 2021 - journals.lww.com
Detecting Heterogeneity of Intervention Effects Using Analys... : Epidemiology Detecting
Heterogeneity of Intervention Effects Using Analysis and Meta-analysis of Differences in Variance …

Heterogeneity in response to repeated intranasal oxytocin in schizophrenia and autism spectrum disorders: A meta‐analysis of variance

D Martins, M Paduraru… - British Journal of …, 2022 - Wiley Online Library
Intranasal oxytocin (OT) has been suggested as a putative adjunctive treatment for patients
with schizophrenia and autism spectrum disorders (ASD). Here, we examine available …

What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis

M Plöderl, MP Hengartner - BMJ open, 2019 - bmjopen.bmj.com
Objectives To investigate if the treatment effect of antidepressants in patients with
depression substantially varies in each patient (patient-by-treatment interaction or treatment …

[HTML][HTML] Treatment effect variability in brain stimulation across psychiatric disorders: A meta-analysis of variance

S Homan, W Muscat, A Joanlanne, N Marousis… - Neuroscience & …, 2021 - Elsevier
Noninvasive brain stimulation methods such as transcranial magnetic stimulation (TMS) and
transcranial direct current stimulation (tDCS) are promising add-on treatments for a number …