Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …

Background Despite PD-L1 (Programmed death receptor ligand-1) expression on tumor
cells and cytotoxic T lymphocytes tumor infiltration in the tumor microenvironment, human …

DNA damage repair (DDR) is a double-edged sword with different roles in cancer
susceptibility and drug resistance. Recent studies suggest that DDR inhibitors affect immune …

Dysregulated transcription due to disruption in histone lysine methylation dynamics is an
established contributor to tumorigenesis,. However, whether analogous pathologic …

Highlights•The first comprehensive compilation of Smyd proteins critical role in cardiac and
skeletal muscle.•Demonstrates the Smyd family's unique ability to regulate transcription …

The p38 mitogen-activated protein kinase (p38MAPK, termed here p38) cascade is a central
signaling pathway that transmits stress and other signals to various intracellular targets in …