Defects in apoptotic cell death can promote cancer and impair responses of malignant cells
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by keeping the cell …

The elimination of unwanted cells by programmed cell death is a common feature of animal
development. Genetic studies in the nematode Caenorhabditis elegans, the fruit fly …

Regulatory T (Treg) cells maintain immune homeostasis and prevent inflammatory and
autoimmune responses. During development, thymocytes bearing a moderately self-reactive …

Abstract The BH3-mimetic ABT-737 and an orally bioavailable compound of the same class,
navitoclax (ABT-263), have shown promising antitumor efficacy in preclinical and early …

Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus
weak T cell receptor binding by self-peptide–MHC complexes. We find this discrimination is …

Macroautophagy serves cellular housekeeping and metabolic functions through delivery of
cytoplasmic constituents for lysosomal degradation. In addition, it may mediate the …

More effective treatment options for elderly acute myeloid leukemia (AML) patients are
needed as only 25–50% of patients respond to standard-of-care therapies, response …

As acute infections resolve, most effector CD8+ T cells die, whereas some persist and
become memory T cells. Recent work showed that subsets of effector CD8+ T cells …

Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling
pathway is critical for lymphocyte development and the establishment of central and …

Repeatedly activated T helper 1 (Th1) cells present during chronic inflammation can
efficiently adapt to the inflammatory milieu, for example, by expressing the transcription …