[HTML][HTML] Space radiation risks to the central nervous system

FA Cucinotta, M Alp, FM Sulzman, M Wang - Life Sciences in Space …, 2014 - Elsevier
Central nervous system (CNS) risks which include during space missions and lifetime risks
due to space radiation exposure are of concern for long-term exploration missions to Mars or …

[HTML][HTML] Behavioral effects of space radiation: A comprehensive review of animal studies

F Kiffer, M Boerma, A Allen - Life sciences in space research, 2019 - Elsevier
As NASA prepares for the first manned mission to Mars in the next 20 years, close attention
has been placed on the cognitive welfare of astronauts, who will likely endure extended …

Female mice are protected from space radiation-induced maladaptive responses

K Krukowski, K Grue, ES Frias, J Pietrykowski… - Brain, behavior, and …, 2018 - Elsevier
Interplanetary exploration will be humankind's most ambitious expedition and the journey
required to do so, is as intimidating as it is intrepid. One major obstacle for successful deep …

The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3

Z Beer, P Vavra, E Atucha, K Rentzing, HJ Heinze… - PLoS …, 2018 - journals.plos.org
A well-accepted model of episodic memory involves the processing of spatial and non-
spatial information by segregated pathways and their association within the hippocampus …

Effects of Proton and Combined Proton and 56Fe Radiation on the Hippocampus

J Raber, AR Allen, S Sharma, B Allen… - Radiation …, 2016 - meridian.allenpress.com
The space radiation environment contains protons and 56Fe, which could pose a significant
hazard to space flight crews during and after missions. The space environment involves …

Combined effects of three high-energy charged particle beams important for space flight on brain, behavioral and cognitive endpoints in B6D2F1 female and male …

J Raber, J Yamazaki, ERS Torres, N Kirchoff… - Frontiers in …, 2019 - frontiersin.org
The radiation environment in deep space includes the galactic cosmic radiation with
different proportions of all naturally occurring ions from protons to uranium. Most …

Progressive increase in the complexity and translatability of rodent testing to assess space-radiation induced cognitive impairment

RA Britten, LL Wellman, LD Sanford - Neuroscience & Biobehavioral …, 2021 - Elsevier
Ground-based rodent models have established that space radiation doses (approximately
those that astronauts will be exposed to on a mission to Mars) significantly impair …

Risks of cognitive detriments after low dose heavy ion and proton exposures

FA Cucinotta, E Cacao - International journal of radiation biology, 2019 - Taylor & Francis
Purpose: Heavy ion and proton brain irradiations occur during space travel and in Hadron
therapy for cancer. Heavy ions produce distinct patterns of energy deposition in neuron cells …

Hippocampal dysfunctions caused by cranial irradiation: a review of the experimental evidence

Y Son, M Yang, H Wang, C Moon - Brain, behavior, and Immunity, 2015 - Elsevier
Cranial irradiation (IR) is commonly used for the treatment of brain tumors but may cause
disastrous brain injury, especially in the hippocampus, which has important cognition and …

Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer's-like transgenic mice

B Liu, RG Hinshaw, KX Le, MA Park, S Wang… - Scientific reports, 2019 - nature.com
Abstract Space travel will expose people to high-energy, heavy particle radiation, and the
cognitive deficits induced by this exposure are not well understood. To investigate the short …