DNA sequencing is in the throes of an enormous technolog-ical shift marked by dramatic
throughput increases, a precipitously dropping per-base cost of raw sequence, and an …

DNA is the central storage molecule of genetic information in the cell, and reading that
information is a central problem in biology. While sequencing technology has made …

Novel applications of micro total analysis systems (μTAS) are addressing fundamental
biological questions, creating new biomedical reagents, and developing innovative cell and …

A significant growth of research in nanofluidics is achieved over the past decade, but the
field is still facing considerable challenges toward the transition from the current physics …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

Comprehensive whole-genome structural variation detection is challenging with current
approaches. With diploid cells as DNA source and the presence of numerous repetitive …

Optical DNA mapping has over the last decade emerged as a very powerful tool for
obtaining long range sequence information from single DNA molecules. In optical DNA …

Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

In recent years, applications and experimental studies of DNA in nanochannels have
stimulated the investigation of the polymer physics of DNA in confinement. Recent advances …

Engineering using liquids confined in channels 10− 1000 nm in dimension, or “extended-
nanofluidics,” is the next target of microfluidic science. Liquid properties at this scale were …