This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Objective Clozapine is the most effective medication for treatment‐refractory schizophrenia,
but it is associated with severe cardiac adverse events including myocarditis and …

Objective Tobacco smoking significantly impacts clozapine blood levels and has substantial
implications on individual efficacy and safety outcomes. By investigating differences in …

Since 1997, studies have found that Asians need lower clozapine doses than Caucasians.
Caucasians with average clozapine metabolism may need from 300 to 600 mg/day to reach …

Seizures are a known adverse effect of clozapine therapy. The literature varies on incidence
rates of seizures, secondary to varying time frames in which each seizure occurred. Tonic …

Previous studies have suggested that a delay in initiating clozapine is one of the predictors
of outcomes in treatment-resistant schizophrenia (TRS). However, whether there is a critical …

Antiepileptic drugs (AEDs) are frequently co-prescribed with new antidepressants (ADs) or
new antipsychotics (APs). A PubMed search with no time limit was used to update the review …

Purpose/Background: In clozapine therapeutic drug monitoring (TDM) studies, Chinese
reached the same concentrations using half the dosage Caucasians use. Defining clozapine …

Introduction Clozapine (CLZ) is the superior drug in treatment of schizophrenia. Serum
concentration of CLZ is associated with clinical response and dose-dependents side effects …

The aim of this retrospective chart-review study was to investigate the relationship between
delayed commencement of clozapine and the level of response in treatment-resistant …