The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Langerhans cells (LCs) reside in the epidermis as a dense network of immune system
sentinels. These cells determine the appropriate adaptive immune response (inflammation …

The decisive role of the epidermis in maintaining body homeostasis prompted studies to
evaluate the changes in epidermal structure and functionality over the lifetime. This …

Background The heterogeneous functions of dermal myeloid cells in antigen presentation,
and scavenging pathogens and cell debris places them centrally in cutaneous inflammation …

Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To
investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic …

Macrophages engulf and digest microbes, cellular debris, and various disease-associated
cells throughout the body. Understanding the dynamics of macrophage gene expression is …

The high prevalence of pain and the at times low efficacy of current treatments represent a
significant challenge to healthcare systems worldwide. Effective treatment strategies require …

Dendritic cells (DC) are mononuclear phagocytes which exhibit a branching (dendritic)
morphology and excel at naïve T cell activation. DC encompass several subsets initially …

More than 15% of the global cancer burden is attributable to infectious agents. Pathogens
that cause persistent infections are strongly associated with cancer, inflammation being a …

We propose Langerhans cell histiocytosis (LCH) is an inflammatory process that is
prolonged by mutations. We hypothesize that Merkel cell polyomavirus (MCPyV) infection …