In patients with Cushing's disease (CD), prompt diagnosis and treatment are essential for
favorable long-term outcomes, although this remains a challenging task. The differential …

Corticotroph tumours are primarily sporadic monoclonal neoplasms and only rarely found in
genetic syndromes. Recurrent mutations in the ubiquitin specific protease 8 (USP8) gene …

Pituitary adenomas are benign tumours comprising approximately 16% of all primary cranial
neoplasms. Functioning pituitary adenomas (prolactinomas, somatotroph, corticotroph …

Pituitary adenomas are frequently occurring neoplasms that produce clinically significant
disease in 1: 1000 of the general population. The pathogenesis of pituitary tumors is a …

Endogenous/exogenous Cushing's syndrome is characterized by a cluster of systemic
manifestations of hypercortisolism, which cause increased cardiovascular risk. Its biological …

Purpose Cushing's disease is the most common cause of endogenous hypercortisolemia
due to a corticotroph pituitary tumor. Up-to-date there is no reliable biomarker of …

Cushing's syndrome (CS) is a complex disorder characterized by the excessive secretion of
cortisol, with Cushing's disease (CD), particularly associated with pituitary tumors, exhibiting …

The potential role of miRNAs in the silencing mechanisms of pituitary neuroendocrine
tumors (PitNETs) has not been addressed. The aim of the present study was to evaluate the …

Cushing's disease represents 60–70% of all cases of Cushing's syndrome, presenting with a
constellation of clinical features associated with sustained hypercortisolism. Molecular …

Pituitary tumours are relatively common in the general population. Most often they occur
sporadically, with somatic mutations accounting for a significant minority of somatotroph and …