Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …

Summary Heterochromatin Protein 1 (HP1) was first discovered in Drosophila as a dominant
suppressor of position-effect variegation and a major component of heterochromatin. The …

Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency.
Here, we report on the generation of a human WS model in human embryonic stem cells …

Senescence is a stable proliferation arrest, associated with an altered secretory pathway,
thought to promote tumor suppression and tissue aging. While chromatin regulation and …

One function of heterochromatin is the epigenetic silencing by sequestration of genes into
transcriptionally repressed nuclear neighborhoods. Heterochromatin protein 1 (HP1) is a …

During division of metazoan cells, the nucleus disassembles to allow chromosome
segregation, and then reforms in each daughter cell. Reformation of the nucleus involves …

Mutations in emerin cause the X-linked recessive form of Emery-Dreifuss muscular
dystrophy (EDMD). Emerin localizes at the inner membrane of the nuclear envelope (NE) …

Background The histone variant histone H2A. X comprises up to 25% of the H2A
complement in mammalian cells. It is rapidly phosphorylated following exposure of cells to …

Nuclear-envelope proteins have been implicated in diverse and fundamental cell functions,
among them transcriptional regulation. Gene expression at the territory of the nuclear …

We show that methylated lysine 9 of histone H3 (Me9H3) is a marker of heterochromatin in
divergent animal species. It localises to both constitutive and facultative heterochromatin …