Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Angiogenesis is involved in physiological and pathological processes in the body. Tumor
angiogenesis is a key factor associated with tumor growth, progression, and metastasis …

Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …

Many diseases appear to be caused by the misregulation of protein maintenance. Such
diseases of protein homeostasis, or “proteostasis,” include loss-of-function diseases (cystic …

HER2 amplification is seen in up to 20% of breast cancers and is associated with an
aggressive phenotype. Trastuzumab, a monoclonal antibody to HER2, accrues significant …

Macrocycles have long been recognized as useful chemical entities for medicine, with
naturally occurring and synthetic macrocycles clinically approved for use as prescription …

Hsp90 is an ATP dependent molecular chaperone protein which integrates multiple
oncogenic pathways. As such, Hsp90 inhibition is a promising anti-cancer strategy. Several …

Angiogenesis has become an attractive target for drug therapy because of its key role in
tumor growth. An extensive array of compounds is currently in preclinical development, with …

Human epidermal growth factor receptor 2 (HER2)‐positive breast cancer (BC) comprises
around 20–30% of all BC subtypes and is correlated with poor prognosis. For many years …

In the last decade, the molecular chaperone HSP90 has emerged as an important target in
cancer therapeutics and has subsequently become the focus of several drug discovery and …