Emerging threats in antifungal-resistant fungal pathogens

D Sanglard - Frontiers in medicine, 2016 - frontiersin.org
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of
antifungal resistance. Resistance has been described for virtually all antifungal agents in …

Clinical implications of globally emerging azole resistance in Aspergillus fumigatus

JF Meis, A Chowdhary, JL Rhodes… - … of the Royal …, 2016 - royalsocietypublishing.org
Aspergillus fungi are the cause of an array of diseases affecting humans, animals and
plants. The triazole antifungal agents itraconazole, voriconazole, isavuconazole and …

Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

J Rhodes, A Abdolrasouli, K Dunne, TR Sewell… - Nature …, 2022 - nature.com
Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to
first-line azole antifungal drugs. However, despite its clinical importance, little is known …

Trends in agricultural triazole fungicide use in the United States, 1992–2016 and possible implications for antifungal-resistant fungi in human disease

M Toda, KD Beer, KM Kuivila, TM Chiller… - Environmental health …, 2021 - ehp.niehs.nih.gov
Background: The fungus Aspergillus fumigatus (A. fumigatus) is the leading cause of
invasive mold infections, which cause severe disease and death in immunocompromised …

Azole-resistant aspergillosis: epidemiology, molecular mechanisms, and treatment

A Chowdhary, C Sharma, JF Meis - The Journal of infectious …, 2017 - academic.oup.com
Aspergillus fumigatus remains the most common species in all pulmonary syndromes,
followed by Aspergillus flavus which is a common cause of allergic rhinosinusitis …

Fungicide effects on human fungal pathogens: cross-resistance to medical drugs and beyond

RW Bastos, L Rossato, GH Goldman… - PLoS Pathogens, 2021 - journals.plos.org
Fungal infections are underestimated threats that affect over 1 billion people, and Candida
spp., Cryptococcus spp., and Aspergillus spp. are the 3 most fatal fungi. The treatment of …

Azole resistance mechanisms in Aspergillus: update and recent advances

A Pérez-Cantero, L López-Fernández, J Guarro… - International journal of …, 2020 - Elsevier
Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA), however other
species of the genus can also cause IA, such as Aspergillus flavus, Aspergillus terreus …

Triazole resistance surveillance in Aspergillus fumigatus

A Resendiz Sharpe, K Lagrou, JF Meis… - Medical …, 2018 - academic.oup.com
Triazole resistance is an increasing concern in the opportunistic mold Aspergillus fumigatus.
Resistance can develop through exposure to azole compounds during azole therapy or in …

Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi

D Hagiwara, A Watanabe, K Kamei… - Frontiers in …, 2016 - frontiersin.org
Invasive aspergillosis is a life-threatening mycosis caused by the pathogenic fungus
Aspergillus. The predominant causal species is Aspergillus fumigatus, and azole drugs are …

Aspergillus fumigatus and aspergillosis: From basics to clinics

A Arastehfar, A Carvalho, J Houbraken… - Studies in …, 2021 - ingentaconnect.com
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …