Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies
B Selvarajah, M Platé, RC Chambers - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis is the concluding pathological outcome and major cause of morbidity and mortality
in a number of common chronic inflammatory, immune-mediated and metabolic diseases …
in a number of common chronic inflammatory, immune-mediated and metabolic diseases …
Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and
limited treatment options. Efforts to identify effective treatments are thwarted by limited …
limited treatment options. Efforts to identify effective treatments are thwarted by limited …
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype
Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease that is primarily
found in the elderly population, and several studies have demonstrated that aging is the …
found in the elderly population, and several studies have demonstrated that aging is the …
Challenges for clinical drug development in pulmonary fibrosis
Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium.
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …
[HTML][HTML] Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis
JC Cooley, N Javkhlan, JA Wilson, DG Foster… - JCI insight, 2023 - ncbi.nlm.nih.gov
Patients with progressive fibrosing interstitial lung diseases (PF-ILDs) carry a poor prognosis
and have limited therapeutic options. A hallmark feature is fibroblast resistance to apoptosis …
and have limited therapeutic options. A hallmark feature is fibroblast resistance to apoptosis …
Induction of accelerated aging in a mouse model
N Cai, Y Wu, Y Huang - Cells, 2022 - mdpi.com
With the global increase of the elderly population, the improvement of the treatment for
various aging-related diseases and the extension of a healthy lifespan have become some …
various aging-related diseases and the extension of a healthy lifespan have become some …
Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis
T Huang, R Lin, Y Su, H Sun, X Zheng, J Zhang… - Nature …, 2023 - nature.com
The use of exogenous mitochondria to replenish damaged mitochondria has been proposed
as a strategy for the treatment of pulmonary fibrosis. However, the success of this strategy is …
as a strategy for the treatment of pulmonary fibrosis. However, the success of this strategy is …
[HTML][HTML] Irreversibility of pulmonary fibrosis
QY Yu, XX Tang - Aging and disease, 2022 - ncbi.nlm.nih.gov
Pulmonary fibrosis, a kind of terminal pathological changes in the lung, is caused by
aberrant wound healing, deposition of extracellular matrix (ECM), and eventually …
aberrant wound healing, deposition of extracellular matrix (ECM), and eventually …
The regenerative power of stem cells: treating bleomycin-induced lung fibrosis
A Vats, P Chaturvedi - Stem Cells and Cloning: Advances and …, 2023 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with no known
cure, characterized by the formation of scar tissue in the lungs, leading to respiratory failure …
cure, characterized by the formation of scar tissue in the lungs, leading to respiratory failure …