With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

Background Sex differences are known to play a role in disease aetiology, progression and
outcome. Previous studies have revealed autosomal epigenetic differences between males …

Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing,
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …

Human evolution has shaped gender differences between males and females. Over the
years, scientific studies have proposed that epigenetic modifications significantly influence …

Increasing evidence points toward epigenetic variants as a risk factor for developing obesity.
We analyzed DNA methylation of the POMC (pro-opiomelanocortin) gene, which is pivotal …

Background Sex is increasingly recognized as a significant factor contributing to the
biological and clinical heterogeneity in AD. There is also growing evidence for the prominent …

The dense neuropil of the central nervous system leaves only limited space for extracellular
substances free. The advent of immunohistochemistry, soon followed by advanced …

Background Growing evidence has demonstrated that DNA methylation (DNAm) plays an
important role in Alzheimer's disease (AD) and that DNAm differences can be detected in the …

Alzheimer's disease (AD) is an age-related, multifaceted neurological disorder associated
with accumulation of aggregated proteins (amyloid Aβ and hyperphosphorylated tau), loss of …