Introduction: The gastrointestinal mucosa constitutes a critical barrier where millions of
microbes and environmental antigens come in close contact with the host immune system …

The chronic intestinal inflammation that characterises Crohn's disease and ulcerative colitis
arises from a complex interplay between host genotype, the immune system, and the …

Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …

We discuss the tripartite pathophysiological circuit of inflammatory bowel disease (IBD),
involving the intestinal microbiota, barrier function, and immune system. Dysfunction in each …

Intestines are organs that not only digest food and absorb nutrients, but also provide a
defense barrier against pathogens and noxious agents ingested. Tight junctions (TJs) are …

Despite the significant health risks resulting from tobacco use, the prevalence of smokers
worldwide remains high. Cigarette smoking is one of the major sources of toxic chemical …

The micronutrients zinc, quercetin, butyrate, indole and berberine were evaluated for their
ability to induce remodeling of epithelial tight junctions (TJs) and enhance barrier integrity in …

Background The inflammatory bowel diseases, Crohn's disease and ulcerative colitis are
related multifactorial diseases. Their pathogenesis is influenced by each individual's …

We have previously shown that vagal nerve stimulation prevents intestinal barrier loss in a
model of severe burn injury in which injury was associated with decreased expression and …

AIM: To investigate the effect of side-stream smoking on gut microflora composition,
intestinal inflammation and expression of tight junction proteins. METHODS: C57BL/6 mice …