Continuous flow synthesis enabling reaction discovery

AI Alfano, J García-Lacuna, OM Griffiths, SV Ley… - Chemical …, 2024 - pubs.rsc.org
This article defines the role that continuous flow chemistry can have in new reaction
discovery, thereby creating molecular assembly opportunities beyond our current …

[HTML][HTML] Heterogeneous photocatalysis in flow chemical reactors

CG Thomson, AL Lee, F Vilela - Beilstein Journal of Organic …, 2020 - beilstein-journals.org
The synergy between photocatalysis and continuous flow chemical reactors has shifted the
paradigms of photochemistry, opening new avenues of research with safer and scalable …

Rapid optimization of photoredox reactions for continuous-flow systems using microscale batch technology

M González-Esguevillas, DF Fernández… - ACS Central …, 2021 - ACS Publications
Photoredox catalysis has emerged as a powerful and versatile platform for the synthesis of
complex molecules. While photocatalysis is already broadly used in small-scale batch …

Flow technology for the genesis and use of (highly) reactive organometallic reagents

M Colella, A Nagaki, R Luisi - Chemistry–A European Journal, 2020 - Wiley Online Library
In the field of organic synthesis, the advent of flow chemistry and flow microreactor
technology represented a tremendous novelty in the way of thinking and performing …

Photoredox catalysis enables decarboxylative cyclization with hypervalent iodine (III) reagents: access to 2, 5-disubstituted 1, 3, 4-oxadiazoles

J Li, XC Lu, Y Xu, JX Wen, GQ Hou, L Liu - Organic Letters, 2020 - ACS Publications
A novel approach to 2, 5-disubstituted 1, 3, 4-oxadiazoles derivatives via a decarboxylative
cyclization reaction by photoredox catalysis between commercially available α …

Development of a continuous flow synthesis of 2-substituted azetines and 3-substituted azetidines by using a common synthetic precursor

M Colella, P Musci, D Cannillo… - The Journal of …, 2021 - ACS Publications
The generation and functionalization, under continuous flow conditions, of two different
lithiated four-membered aza-heterocycles is reported. N-Boc-3-iodoazetidine acts as a …

(2‐Ethylhexyl) sodium: A Hexane‐Soluble Reagent for Br/Na‐Exchanges and Directed Metalations in Continuous Flow

JH Harenberg, N Weidmann… - Angewandte Chemie …, 2021 - Wiley Online Library
We report the on‐demand generation of hexane‐soluble (2‐ethylhexyl) sodium (1) from 3‐
(chloromethyl) heptane (2) using a sodium‐packed‐bed reactor under continuous flow …

Continuous flow sodiation of substituted acrylonitriles, alkenyl sulfides and acrylates

JH Harenberg, N Weidmann… - Angewandte Chemie …, 2021 - Wiley Online Library
The sodiation of substituted acrylonitriles and alkenyl sulfides in a continuous flow set‐up
using NaDA (sodium diisopropylamide) in EtNMe2 or NaTMP (sodium 2, 2, 6, 6 …

Continuous‐Flow Divergent Lithiation of 2, 3‐Dihalopyridines: Deprotolithiation versus Halogen Dance

T Brégent, MV Ivanova, T Poisson… - … A European Journal, 2022 - Wiley Online Library
We describe herein the first halogen dance (HD) in continuous flow on 2‐chloro‐3‐
bromopyridine by selectively trapping a (pyridin‐4‐yl) lithium species that is known to …

[HTML][HTML] Flow chemistry as green technology for the genesis and use of organometallic reagents in the synthesis of key building blocks and APIs–An update

P Natho, R Luisi - Tetrahedron Green Chem, 2023 - Elsevier
The advent of flow chemistry and flow microreactor technology in organic synthesis has
added a series of options to the toolbox of synthetic chemists by enabling access to …