Continuous flow synthesis enabling reaction discovery
AI Alfano, J García-Lacuna, OM Griffiths, SV Ley… - Chemical …, 2024 - pubs.rsc.org
This article defines the role that continuous flow chemistry can have in new reaction
discovery, thereby creating molecular assembly opportunities beyond our current …
discovery, thereby creating molecular assembly opportunities beyond our current …
[HTML][HTML] Heterogeneous photocatalysis in flow chemical reactors
The synergy between photocatalysis and continuous flow chemical reactors has shifted the
paradigms of photochemistry, opening new avenues of research with safer and scalable …
paradigms of photochemistry, opening new avenues of research with safer and scalable …
Rapid optimization of photoredox reactions for continuous-flow systems using microscale batch technology
M González-Esguevillas, DF Fernández… - ACS Central …, 2021 - ACS Publications
Photoredox catalysis has emerged as a powerful and versatile platform for the synthesis of
complex molecules. While photocatalysis is already broadly used in small-scale batch …
complex molecules. While photocatalysis is already broadly used in small-scale batch …
Flow technology for the genesis and use of (highly) reactive organometallic reagents
In the field of organic synthesis, the advent of flow chemistry and flow microreactor
technology represented a tremendous novelty in the way of thinking and performing …
technology represented a tremendous novelty in the way of thinking and performing …
Photoredox catalysis enables decarboxylative cyclization with hypervalent iodine (III) reagents: access to 2, 5-disubstituted 1, 3, 4-oxadiazoles
J Li, XC Lu, Y Xu, JX Wen, GQ Hou, L Liu - Organic Letters, 2020 - ACS Publications
A novel approach to 2, 5-disubstituted 1, 3, 4-oxadiazoles derivatives via a decarboxylative
cyclization reaction by photoredox catalysis between commercially available α …
cyclization reaction by photoredox catalysis between commercially available α …
Development of a continuous flow synthesis of 2-substituted azetines and 3-substituted azetidines by using a common synthetic precursor
M Colella, P Musci, D Cannillo… - The Journal of …, 2021 - ACS Publications
The generation and functionalization, under continuous flow conditions, of two different
lithiated four-membered aza-heterocycles is reported. N-Boc-3-iodoazetidine acts as a …
lithiated four-membered aza-heterocycles is reported. N-Boc-3-iodoazetidine acts as a …
(2‐Ethylhexyl) sodium: A Hexane‐Soluble Reagent for Br/Na‐Exchanges and Directed Metalations in Continuous Flow
JH Harenberg, N Weidmann… - Angewandte Chemie …, 2021 - Wiley Online Library
We report the on‐demand generation of hexane‐soluble (2‐ethylhexyl) sodium (1) from 3‐
(chloromethyl) heptane (2) using a sodium‐packed‐bed reactor under continuous flow …
(chloromethyl) heptane (2) using a sodium‐packed‐bed reactor under continuous flow …
Continuous flow sodiation of substituted acrylonitriles, alkenyl sulfides and acrylates
JH Harenberg, N Weidmann… - Angewandte Chemie …, 2021 - Wiley Online Library
The sodiation of substituted acrylonitriles and alkenyl sulfides in a continuous flow set‐up
using NaDA (sodium diisopropylamide) in EtNMe2 or NaTMP (sodium 2, 2, 6, 6 …
using NaDA (sodium diisopropylamide) in EtNMe2 or NaTMP (sodium 2, 2, 6, 6 …
Continuous‐Flow Divergent Lithiation of 2, 3‐Dihalopyridines: Deprotolithiation versus Halogen Dance
We describe herein the first halogen dance (HD) in continuous flow on 2‐chloro‐3‐
bromopyridine by selectively trapping a (pyridin‐4‐yl) lithium species that is known to …
bromopyridine by selectively trapping a (pyridin‐4‐yl) lithium species that is known to …
[HTML][HTML] Flow chemistry as green technology for the genesis and use of organometallic reagents in the synthesis of key building blocks and APIs–An update
The advent of flow chemistry and flow microreactor technology in organic synthesis has
added a series of options to the toolbox of synthetic chemists by enabling access to …
added a series of options to the toolbox of synthetic chemists by enabling access to …