Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

Covering: 2010 up to 2016 Deconvoluting the mode of action of natural products and drugs
remains one of the biggest challenges in chemistry and biology today. Chemical proteomics …

Bacterial proteases are an extensive collection of enzymes that have vital roles in cell
viability, stress response and pathogenicity. Although their perturbation clearly offers the …

Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes.
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …

This article presents several covalent inhibitors, including examples of successful drugs, as
well as highly selective, irreversible inhibitors of emerging therapeutic targets, such as fatty …

Highlights•Electrophiles can show distinct amino-acid selectivities in proteomes.•The
judicious selection of an electrophile is critical to various chemical-proteomic applications.•A …

Cycles of depalmitoylation and repalmitoylation critically control the steady-state localization
and function of various peripheral membrane proteins, such as Ras proto-oncogene …

Covering: 1900 to 2011 The study of biologically active natural products has resulted in
seminal contributions to our understanding of living systems. In the case of electrophilic …

Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and
pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been …

Malaria has been a global epidemic health threat since ancient times. It still claims roughly
half a million lives every year in this century. Artemisinin and its derivatives, are frontline …