Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during
embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds …

Epithelial ovarian cancer (EOC) is the deadliest female malignancy. The Wnt/β-catenin
pathway plays critical roles in regulating embryonic development and physiological …

Metabolic and haemodynamic perturbations and their interaction drive the development of
diabetic kidney disease (DKD) and its progression towards end stage renal disease (ESRD) …

Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-
associated vascular changes and their relation to tissue aging and pathology are poorly …

Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-
like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) …

The WNT (Wingless/Integrated) signaling pathway is implicated in various stages of
glioblastoma, which is an aggressive brain tumor for which therapeutic options are limited …

The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif
(TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play …

Sufficient oxygen is required to maintain normal cellular and physiological function, such as
a creature's development, breeding, and homeostasis. Lately, some researchers have …

Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors
mainly occurring in children, adolescents and young adults. Current standard therapy …

The Notch signaling pathway is an evolutionarily conserved cell signaling system known to
be involved in vascular development and function. Recent evidence suggests that …