Immunobiology and pathogenesis of hepatitis B virus infection
M Iannacone, LG Guidotti - Nature Reviews Immunology, 2022 - nature.com
Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …
Mechanisms of HBV-induced hepatocellular carcinoma
M Levrero, J Zucman-Rossi - Journal of hepatology, 2016 - Elsevier
Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg
Chronic hepatitis B virus (HBV) infection is a major health concern worldwide, frequently
leading to liver cirrhosis, liver failure, and hepatocellular carcinoma. Evidence suggests that …
leading to liver cirrhosis, liver failure, and hepatocellular carcinoma. Evidence suggests that …
[HTML][HTML] HBV DNA integration: molecular mechanisms and clinical implications
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity
and mortality. One peculiar observation in cells infected with HBV (or with closely‑related …
and mortality. One peculiar observation in cells infected with HBV (or with closely‑related …
HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant
WS Mason, US Gill, S Litwin, Y Zhou, S Peri, O Pop… - Gastroenterology, 2016 - Elsevier
Background & Aims Chronic infection with hepatitis B virus (HBV) progresses through
different phases. The first, called the immune-tolerant phase, has been associated with a …
different phases. The first, called the immune-tolerant phase, has been associated with a …
[HTML][HTML] Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load
MA Meier, D Calabrese, A Suslov, LM Terracciano… - Journal of …, 2021 - Elsevier
Background & Aims Loss of serum HBsAg is a hallmark of spontaneous and therapy
induced resolution of HBV infection, since it generally reflects a profound decrease in viral …
induced resolution of HBV infection, since it generally reflects a profound decrease in viral …
The evolution and clinical impact of hepatitis B virus genome diversity
The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …
[HTML][HTML] Increasing on-treatment hepatocellular carcinoma risk with decreasing baseline viral load in HBeAg-positive chronic hepatitis B
BACKGROUND It is unclear whether the level of serum hepatitis B virus (HBV) DNA at
baseline affects the on-treatment risk of hepatocellular carcinoma (HCC) in hepatitis B e …
baseline affects the on-treatment risk of hepatocellular carcinoma (HCC) in hepatitis B e …
Global strategies are required to cure and eliminate HBV infection
Chronic HBV infection results in> 1 million deaths per year from cirrhosis and liver cancer.
No known cure for chronic HBV exists, due in part to the continued presence of …
No known cure for chronic HBV exists, due in part to the continued presence of …
[HTML][HTML] HBV-integration studies in the clinic: role in the natural history of infection
T Pollicino, G Caminiti - Viruses, 2021 - mdpi.com
Hepatitis B virus (HBV) infection is a major global health problem causing acute and chronic
liver disease that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). HBV …
liver disease that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). HBV …