Osteosarcoma, one of the common malignant tumors in the skeletal system, originates in
mesenchymal tissue, and the most susceptible area of occurrence is the metaphysis with its …

The mammalian cell cycle has been extensively studied regarding cancer etiology,
progression, and therapeutic intervention. The canonical cell cycle framework is supported …

Osteosarcoma (OS) is the most common type of bone sarcoma. Despite the availability of
multimodal treatment with surgery and chemotherapy, the clinical results remain …

PURPOSE Osteosarcoma risk stratification, on the basis of the presence of metastatic
disease at diagnosis and histologic response to chemotherapy, has remained unchanged …

Alternative lengthening of telomeres (ALT) supports telomere maintenance in 10–15% of
cancers, thus representing a compelling target for therapy. By performing anti-cancer …

Poly (ADP-ribose) polymerase inhibitors (PARPis) are approved for cancer therapy
according to their synthetic lethal interactions, and clinical trials have been applied in non …

Conventional high-grade osteosarcoma (OS) is the most common primary cancer of bone
and it typically affects the extremities of adolescents. OS has a complex karyotype, and …

The retinoblastoma tumor suppressor protein (RB) interacts physically and functionally with
a number of epigenetic modifying enzymes to control transcriptional regulation, respond to …

Background There is growing evidence supporting multidisciplinary molecular tumor boards
(MTB) in solid tumors whereas hematologic malignancies remain underrepresented in this …

Microhomology-mediated end joining (MMEJ) is a highly mutagenic pathway to repair
double-strand breaks (DSBs). MMEJ was thought to be a backup pathway of homologous …