Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can lead to clinical
manifestations of systemic diseases. Its leading features include chronic synovial …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the lining of the synovial joints and is associated with progressive disability, premature …

The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine Skip to main
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Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant
therapeutic advances. The pathogenesis of RA is complex and includes many cell types …

Rheumatoid arthritis (RA), a systemic disease, is characterized by a chronic inflammatory
reaction in the synovium of joints and is associated with degeneration of cartilage and …

Swelling and the progressive destruction of articular cartilage are major characteristics of
rheumatoid arthritis (RA), a systemic autoimmune disease that directly affects the synovial …

Objectives: To characterize cell surface receptors, their ligands, and their proteins in the 2
major pathways of apoptosis; the components that promote/suppress these interactions; the …

Rheumatoid arthritis (RA) is a chronic inflammatory synovitis that is dominated by the
presence of macrophages, lymphocytes and synovial fibroblasts, which leads to the …

Oxidative stress at sites of chronic inflammation can cause permanent genetic changes. The
development of mutations in the p53 tumor suppressor gene and other key regulatory genes …

Background: Matrix metalloproteinases (MMPs) have a pivotal role in the destruction of
cartilage in rheumatoid arthritis (RA), which is mediated by the fibroblast-like synoviocytes …