Applications of focused ultrasound-mediated blood-brain barrier opening
The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
[HTML][HTML] Sonogenetics: recent advances and future directions
T Liu, MH Choi, J Zhu, T Zhu, J Yang, N Li, Z Chen… - Brain Stimulation, 2022 - Elsevier
Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for
noninvasive and selective control of neural activity. It is a promising tool for studying neural …
noninvasive and selective control of neural activity. It is a promising tool for studying neural …
Ectopic expression of a mechanosensitive channel confers spatiotemporal resolution to ultrasound stimulations of neurons for visual restoration
S Cadoni, C Demené, I Alcala, M Provansal… - Nature …, 2023 - nature.com
Remote and precisely controlled activation of the brain is a fundamental challenge in the
development of brain–machine interfaces for neurological treatments. Low-frequency …
development of brain–machine interfaces for neurological treatments. Low-frequency …
The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation
J Zhu, Q Xian, X Hou, KF Wong, T Zhu… - Proceedings of the …, 2023 - National Acad Sciences
Transcranial low-intensity ultrasound is a promising neuromodulation modality, with the
advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy …
advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy …
Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound
Torpor is an energy-conserving state in which animals dramatically decrease their metabolic
rate and body temperature to survive harsh environmental conditions. Here, we report the …
rate and body temperature to survive harsh environmental conditions. Here, we report the …
Modulation of deep neural circuits with sonogenetics
Q Xian, Z Qiu, S Murugappan, S Kala… - Proceedings of the …, 2023 - National Acad Sciences
Noninvasive control of neuronal activity in the deep brain can be illuminating for probing
brain function and treating dysfunctions. Here, we present a sonogenetic approach for …
brain function and treating dysfunctions. Here, we present a sonogenetic approach for …
Incisionless targeted adeno-associated viral vector delivery to the brain by focused ultrasound-mediated intranasal administration
Background Adeno-associated viral (AAV) vectors are currently the leading platform for
gene therapy with the potential to treat a variety of central nervous system (CNS) diseases …
gene therapy with the potential to treat a variety of central nervous system (CNS) diseases …
Ultrasound-responsive systems as components for smart materials
Smart materials can respond to stimuli and adapt their responses based on external cues
from their environments. Such behavior requires a way to transport energy efficiently and …
from their environments. Such behavior requires a way to transport energy efficiently and …
[HTML][HTML] Non-invasive optogenetics with ultrasound-mediated gene delivery and red-light excitation
Optogenetics has revolutionized the capability of controlling genetically modified neurons in
vitro and in vivo and has become an indispensable neuroscience tool. Using light as a …
vitro and in vivo and has become an indispensable neuroscience tool. Using light as a …
Activation of mechanosensitive ion channels by ultrasound
Mechanosensitive channels (MSCs) play an important role in how cells transduce
mechanical stimuli into electrical or chemical signals, which provides an interventional …
mechanical stimuli into electrical or chemical signals, which provides an interventional …