Advances in Vaccine Development for Chlamydia trachomatis
TB Poston - Pathogens and Disease, 2024 - academic.oup.com
Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection globally.
Antibiotic treatment is highly effective, but infection is often asymptomatic resulting in most …
Antibiotic treatment is highly effective, but infection is often asymptomatic resulting in most …
Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR …
Activation of the mechanistic target of rapamycin (mTOR) is a key metabolic checkpoint of
pro-inflammatory T-cell development that contributes to the pathogenesis of autoimmune …
pro-inflammatory T-cell development that contributes to the pathogenesis of autoimmune …
Conserved molecular chaperone PrsA stimulates protective immunity against group A Streptococcus
CY Lai, JX Xie, MC Lai, ZY Wu, JS Lin, YT Huang… - npj Vaccines, 2024 - nature.com
Abstract Group A Streptococcus (GAS) is a significant human pathogen that poses a global
health concern. However, the development of a GAS vaccine has been challenging due to …
health concern. However, the development of a GAS vaccine has been challenging due to …
Disruption of IL-17-mediated immunosurveillance in the respiratory mucosa results in invasive Streptococcus pyogenes infection
JL Mills, A Lepletier, V Ozberk, J Dooley… - Frontiers in …, 2024 - frontiersin.org
Introduction Streptococcus pyogenes is a Gram-positive pathogen that causes a significant
global burden of skin pyoderma and pharyngitis. In some cases, infection can lead to severe …
global burden of skin pyoderma and pharyngitis. In some cases, infection can lead to severe …
IL-17B alleviates the pathogenesis of systemic lupus erythematosus by inhibiting FASN-mediated differentiation of B cells
Y Xiao, Y Hu, Y Gao, L Wang, L Zhang, Q Ma, Z Ning… - JCI insight, 2024 - insight.jci.org
Abstract The interleukin-17 (IL-17) family of cytokines has emerged as a critical player in
autoimmune disease, including systemic lupus erythematosus (SLE). However, the role of IL …
autoimmune disease, including systemic lupus erythematosus (SLE). However, the role of IL …