Signal transducer and activator of transcription (STAT) 3 is one of the most complex
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …

Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally …

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly
understood. Here we identify nuclear factor IA (NFIA) as a molecular switch inducing human …

The hope of developing new transplantation therapies for degenerative diseases is limited
by inefficient stem cell growth and immunological incompatibility with the host,. Here we …

Neurons have long held the spotlight as the central players of the nervous system, but we
must remember that we have equal numbers of astrocytes and neurons in the brain. Are …

During development of the mammalian nervous system, neural stem cells generate neurons
first and glia second, thereby allowing the initial establishment of neural circuitry, and …

Signal transducer and activator of transcription 3 (STAT3) regulates diverse cellular
processes, including cell growth, differentiation, and apoptosis, and is frequently activated …

Recent research has changed the perception of glia from being no more than silent
supportive cells of neurons to being dynamic partners participating in brain metabolism and …

The mechanisms by which neural stem cells give rise to neurons, astrocytes, or
oligodendrocytes are beginning to be elucidated. However, it is not known how the …

During neocortical development, neural precursor cells (NPCs, or neural stem cells)
produce neurons first and astrocytes later. Although the timing of the fate switch from …