Infectious diseases are the second most important cause of human death worldwide;
Staphylococcus aureus (S. aureus) is a very common human pathogenic microorganism that …

Due to the long-term and widespread use of antibiotics in clinic, the problem of bacterial
resistance is increasingly serious, and the development of new drugs to treat drug-resistant …

Staphylococcus aureus is one of the leading hospital-associated and community-associated
pathogens, which has caused a global public health concern. The emergence of methicillin …

Vancomycin-resistant enterococci infections are of great public health significance due to
limited therapeutic options. We investigated epidemiological trends and risk factors of …

Chirality plays an important role in the development of many pharmaceuticals, being a
general property of 'handedness'; nevertheless, a large number of pharmaceuticals are still …

Currently, the efficacy of antibiotics is severely affected by the emergence of the
antimicrobial resistance phenomenon, leading to increased morbidity and mortality …

In recent years, multidrug-resistant (MDR) bacteria have increased rapidly, representing a
major threat to human health. This problem has created an urgent need to identify …

It has been nearly 50 years since the golden age of antibiotic discovery (1945–1975) ended;
yet, we still struggle to identify novel drug targets and to deliver new chemical classes of …

Five-membered heterocycles are essential structural components in various antibacterial
drugs; the physicochemical properties of a five-membered heterocycle can play a crucial …

The Gram-positive anaerobic bacterium Clostridioides difficile (CD) can produce intense
exotoxins, contributing to nosocomial infections, and it is the most common cause of health …