Chatgpt-powered conversational drug editing using retrieval and domain feedback
Recent advancements in conversational large language models (LLMs), such as ChatGPT,
have demonstrated remarkable promise in various domains, including drug discovery …
have demonstrated remarkable promise in various domains, including drug discovery …
Development and Clinical Applications of Therapeutic Cancer Vaccines with Individualized and Shared Neoantigens
Q Hao, Y Long, Y Yang, Y Deng, Z Ding, L Yang, Y Shu… - Vaccines, 2024 - mdpi.com
Neoantigens, presented as peptides on the surfaces of cancer cells, have recently been
proposed as optimal targets for immunotherapy in clinical practice. The promising outcomes …
proposed as optimal targets for immunotherapy in clinical practice. The promising outcomes …
RLpMIEC: High-Affinity Peptide Generation Targeting Major Histocompatibility Complex-I Guided and Interpreted by Interaction Spectrum-Navigated Reinforcement …
Q Deng, Z Wang, S Xiang, Q Wang, Y Liu… - Journal of Chemical …, 2024 - ACS Publications
Major histocompatibility complex (MHC) plays a vital role in presenting epitopes (short
peptides from pathogenic proteins) to T-cell receptors (TCRs) to trigger the subsequent …
peptides from pathogenic proteins) to T-cell receptors (TCRs) to trigger the subsequent …
Integrating Reinforcement Learning and Monte Carlo Tree Search for enhanced neoantigen vaccine design
Y Lin, J Ma, H Yuan, Z Chen, X Xu… - Briefings in …, 2024 - academic.oup.com
Recent advances in cancer immunotherapy have highlighted the potential of neoantigen-
based vaccines. However, the design of such vaccines is hindered by the possibility of weak …
based vaccines. However, the design of such vaccines is hindered by the possibility of weak …
Multi-strategies embedded framework for neoantigen vaccine maturation
Effective cancer immunotherapy hinges on the precise recognition of neoantigens,
presented as binary complexes with major histocompatibility complex (MHC) molecules, by …
presented as binary complexes with major histocompatibility complex (MHC) molecules, by …