The repositioning or “repurposing” of existing therapies for alternative disease indications is
an attractive approach that can save significant investments of time and money during drug …

The advent of next-generation sequencing technologies has greatly promoted advances in
the study of human diseases at the genomic, transcriptomic, and epigenetic levels. Exome …

People with severe mental illness have a considerably shorter lifespan than the general
population. This excess mortality is mainly due to physical illness. Next to mental illness …

Genome-wide expression profiling of gene transcripts has been successfully applied in
biomedical discovery for over a decade. Based on the premises of this technology …

Approximately 75% of breast tumors express the estrogen receptor (ER), and women with
these tumors will receive endocrine therapy. Unfortunately, up to 50% of these patients will …

Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components regulating the
CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re …

Covering: up to February 2016 Identification of the target proteins of natural products is
pivotal to understanding the mechanisms of action to develop natural products for use as …

Cyclin E2, but not cyclin E1, is included in several gene signatures that predict disease
progression in either tamoxifen-resistant or metastatic breast cancer. We therefore examined …

Objective A recent meta‐analysis showed that breast cancer probably is more common in
female patients with schizophrenia than in the general population (effect size= 1.25, P< …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …