Molecular Chaperones of Leishmania: Central Players in Many Stress‐Related and ‐Unrelated Physiological Processes
JM Requena, AM Montalvo… - BioMed research …, 2015 - Wiley Online Library
Molecular chaperones are key components in the maintenance of cellular homeostasis and
survival, not only during stress but also under optimal growth conditions. Folding of nascent …
survival, not only during stress but also under optimal growth conditions. Folding of nascent …
Systems biology of autophagy in leishmanial infection and its diverse role in precision medicine
V Guhe, P Ingale, A Tambekar, S Singh - Frontiers in Molecular …, 2023 - frontiersin.org
Autophagy is a contentious issue in leishmaniasis and is emerging as a promising
therapeutic regimen. Published research on the impact of autophagic regulation on …
therapeutic regimen. Published research on the impact of autophagic regulation on …
Characterization of the interaction between eupatorin and bovine serum albumin by spectroscopic and molecular modeling methods
H Xu, N Yao, H Xu, T Wang, G Li, Z Li - International Journal of Molecular …, 2013 - mdpi.com
This study investigated the interaction between eupatorin and bovine serum albumin (BSA)
using ultraviolet-visible (UV-vis) absorption, fluorescence, synchronous fluorescence …
using ultraviolet-visible (UV-vis) absorption, fluorescence, synchronous fluorescence …
Search for Higgs boson decays into pairs of light (pseudo) scalar particles in the γγjj final state in pp collisions at s= 13TeV with the ATLAS detector
M Aaboud, G Aad, B Abbott, B Abeloos, SH Abidi… - Physics Letters B, 2018 - Elsevier
This Letter presents a search for exotic decays of the Higgs boson to a pair of new (pseudo)
scalar particles, H→ aa, where the a particle has a mass in the range 20–60 GeV, and …
scalar particles, H→ aa, where the a particle has a mass in the range 20–60 GeV, and …
Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)
RP Siqueira, ÉAA Barbosa, MD Polêto, GL Righetto… - PloS one, 2015 - journals.plos.org
Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis of
several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role …
several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role …
Human mitochondrial Hsp70 (mortalin): shedding light on ATPase activity, interaction with adenosine nucleotides, solution structure and domain organization
The human mitochondrial Hsp70, also called mortalin, is of considerable importance for
mitochondria biogenesis and the correct functioning of the cell machinery. In the …
mitochondria biogenesis and the correct functioning of the cell machinery. In the …
Aspergillus fumigatus Hsp90 interacts with the main components of the cell wall integrity pathway and cooperates in heat shock and cell wall stress adaptation
MC Rocha, K Minari, JHTM Fabri… - Cellular …, 2021 - Wiley Online Library
The initiation of Aspergillus fumigatus infection occurs via dormant conidia deposition into
the airways. Therefore, conidial germination and subsequent hyphal extension and growth …
the airways. Therefore, conidial germination and subsequent hyphal extension and growth …
PtII, PdII and AuIII complexes with a thiosemicarbazone derived from diacethylmonooxime: Structural analysis, trypanocidal activity, cytotoxicity and first insight into the …
ACR Goncalves, ZA Carneiro, CG Oliveira… - European Journal of …, 2017 - Elsevier
New complexes of composition [MX (HL1)](M= Pt II, Pd II, X= Cl− or I−) and [MX (L1)](M= Au
III, X= Cl−; M= Pt II, Pd II, X= PPh 3) have been synthesized using a potentially tridentate …
III, X= Cl−; M= Pt II, Pd II, X= PPh 3) have been synthesized using a potentially tridentate …
A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90
LC Palma, LFGR Ferreira, ALOA Petersen, BRS Dias… - Scientific reports, 2019 - nature.com
Leishmaniasis is a neglected disease that affects millions of individuals around the world.
Regardless of clinical form, treatment is based primarily on the use of pentavalent …
Regardless of clinical form, treatment is based primarily on the use of pentavalent …
Design, synthesis and in vitro investigation of novel basic celastrol carboxamides as bio-inspired leishmanicidal agents endowed with inhibitory activity against …
I Bassanini, S Parapini, EE Ferrandi, E Gabriele… - Biomolecules, 2021 - mdpi.com
The natural triterpene celastrol (CE) is here used as lead compound for the design and
synthesis of a panel of eleven CE carboxamides that were tested in vitro for their growth …
synthesis of a panel of eleven CE carboxamides that were tested in vitro for their growth …