Prevention of acute exacerbations of COPD: American college of chest physicians and Canadian thoracic society guideline

GJ Criner, J Bourbeau, RL Diekemper, DR Ouellette… - Chest, 2015 - Elsevier
BACKGROUND: COPD is a major cause of morbidity and mortality in the United States as
well as throughout the rest of the world. An exacerbation of COPD (periodic escalations of …

Pharmacology and therapeutics of bronchodilators

M Cazzola, CP Page, L Calzetta, MG Matera - Pharmacological Reviews, 2012 - ASPET
Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

The scientific rationale for combining long-acting β2-agonists and muscarinic antagonists in COPD

M Cazzola, M Molimard - Pulmonary pharmacology & therapeutics, 2010 - Elsevier
Bronchodilators are the cornerstone of pharmacological management of COPD. For patients
whose conditions are not sufficiently controlled by monotherapy, combining bronchodilators …

[HTML][HTML] Efficacy and safety of fixed-dose combinations of aclidinium bromide/formoterol fumarate: the 24-week, randomized, placebo-controlled AUGMENT COPD …

AD D'Urzo, SI Rennard, EM Kerwin, V Mergel… - Respiratory …, 2014 - Springer
Background Combining two long-acting bronchodilators with complementary mechanisms of
action may provide treatment benefits to patients with chronic obstructive pulmonary disease …

Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD

JA Van Noord, JL Aumann, E Janssens… - European …, 2005 - Eur Respiratory Soc
This study compared the bronchodilator effects of tiotropium, formoterol and both combined
in chronic obstructive pulmonary disease (COPD). A total of 71 COPD patients (mean forced …

COPD: current therapeutic interventions and future approaches

PJ Barnes, RA Stockley - European Respiratory Journal, 2005 - Eur Respiratory Soc
Although long-acting bronchodilators have been an important advance for the management
of chronic obstructive pulmonary disease (COPD), these drugs do not deal with the …

支气管舒张剂和吸入糖皮质激素在慢性阻塞性肺疾病中的应用

姚婉贞, 常春 - 中华结核和呼吸杂志, 2007 - cqvip.com
慢性阻塞性肺疾病(COPD) 是一种慢性呼吸系统疾病, 其主要特征为肺功能的缓慢减退及进行性
气流受限, 气流受限不完全可逆. 通过积极的预防和治疗可以有效缓解症状, 提高运动耐量 …

Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD

JA Van Noord, JL Aumann, E Janssens, J Verhaert… - Chest, 2006 - Elsevier
Background The combination of short-acting β 2-agonists and anticholinergics in the
treatment of COPD has been well documented, but data on combination of long-acting …

Monitoring in chronic disease: a rational approach

P Glasziou, L Irwig, D Mant - Bmj, 2005 - bmj.com
The ritual of routine visits for most chronic diseases usually includes monitoring to check on
the progress or regress of the disease and the development of complications. Such checks …

[HTML][HTML] Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease

DP Tashkin, GT Ferguson - Respiratory research, 2013 - Springer
Chronic obstructive pulmonary disease (COPD) represents a significant cause of global
morbidity and mortality, with a substantial economic impact. Recent changes in the Global …