More than a decade of genetic research on the Denisovans
Denisovans, a group of now extinct humans who lived in Eastern Eurasia in the Middle and
Late Pleistocene, were first identified from DNA sequences just over a decade ago. Only ten …
Late Pleistocene, were first identified from DNA sequences just over a decade ago. Only ten …
Something old, something borrowed: admixture and adaptation in human evolution
M Dannemann, F Racimo - Current opinion in genetics & development, 2018 - Elsevier
The sequencing of ancient DNA from archaic humans—Neanderthals and Denisovans—has
revealed that modern and archaic humans interbred at least twice during the Pleistocene …
revealed that modern and archaic humans interbred at least twice during the Pleistocene …
[HTML][HTML] Evidence that RNA viruses drove adaptive introgression between Neanderthals and modern humans
Neanderthals and modern humans interbred at least twice in the past 100,000 years. While
there is evidence that most introgressed DNA segments from Neanderthals to modern …
there is evidence that most introgressed DNA segments from Neanderthals to modern …
The history and evolution of the Denisovan-EPAS1 haplotype in Tibetans
Recent studies suggest that admixture with archaic hominins played an important role in
facilitating biological adaptations to new environments. For example, interbreeding with …
facilitating biological adaptations to new environments. For example, interbreeding with …
[HTML][HTML] Evolutionary selection and constraint on human knee chondrocyte regulation impacts osteoarthritis risk
D Richard, Z Liu, J Cao, AM Kiapour, J Willen… - Cell, 2020 - cell.com
During human evolution, the knee adapted to the biomechanical demands of bipedalism by
altering chondrocyte developmental programs. This adaptive process was likely not without …
altering chondrocyte developmental programs. This adaptive process was likely not without …
A need for standardized reporting of introgression: Insights from studies across eukaryotes
With the rise of affordable next-generation sequencing technology, introgression—or the
exchange of genetic materials between taxa—has become widely perceived to be a …
exchange of genetic materials between taxa—has become widely perceived to be a …
Hybridization in human evolution: Insights from other organisms
RR Ackermann, ML Arnold, MD Baiz… - … : Issues, News, and …, 2019 - Wiley Online Library
During the late Pleistocene, isolated lineages of hominins exchanged genes thus
influencing genomic variation in humans in both the past and present. However, the …
influencing genomic variation in humans in both the past and present. However, the …
[HTML][HTML] Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde
Humans have undergone large migrations over the past hundreds to thousands of years,
exposing ourselves to new environments and selective pressures. Yet, evidence of ongoing …
exposing ourselves to new environments and selective pressures. Yet, evidence of ongoing …
[HTML][HTML] Fluctuating selection and the determinants of genetic variation
Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands
of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating …
of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating …
[HTML][HTML] Impact of historic migrations and evolutionary processes on human immunity
J Domínguez-Andrés, MG Netea - Trends in Immunology, 2019 - cell.com
The evolution of mankind has constantly been influenced by the pathogens encountered.
The various populations of modern humans that ventured out of Africa adapted to different …
The various populations of modern humans that ventured out of Africa adapted to different …