Harnessing synthetic biology to engineer organoids and tissues

C Trentesaux, T Yamada, OD Klein, WA Lim - Cell Stem Cell, 2023 - cell.com
The development of an organism depends on intrinsic genetic programs of progenitor cells
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …

Programmable interactions with biomimetic DNA linkers at fluid membranes and interfaces

BM Mognetti, P Cicuta… - Reports on progress in …, 2019 - iopscience.iop.org
At the heart of the structured architecture and complex dynamics of biological systems are
specific and timely interactions operated by biomolecules. In many instances, biomolecular …

A quantitative assessment of the dynamic modification of lipid–DNA probes on live cell membranes

Y Bagheri, S Chedid, F Shafiei, B Zhao, M You - Chemical science, 2019 - pubs.rsc.org
Synthetic lipid–DNA probes have recently attracted much attention for cell membrane
analysis, transmembrane signal transduction, and regulating intercellular networks. These …

DNA nanostructures for exploring cell–cell communication

Y Wang, Y Xiong, K Shi, CY Effah, L Song… - Chemical Society …, 2024 - pubs.rsc.org
The process of coordinating between the same or multiple types of cells to jointly execute
various instructions in a controlled and carefully regulated environment is a very appealing …

Design principles for pluripotent stem cell‐derived organoid engineering

TP Silva, JP Cotovio, E Bekman… - Stem Cells …, 2019 - Wiley Online Library
Human morphogenesis is a complex process involving distinct microenvironmental and
physical signals that are manipulated in space and time to give rise to complex tissues and …

Programming the self-organization of endothelial cells into perfusable microvasculature

KA Cabral, V Srivastava, AJ Graham… - … Engineering Part A, 2023 - liebertpub.com
The construction of three-dimensional (3D) microvascular networks with defined structures
remains challenging. Emerging bioprinting strategies provide a means of patterning …

Controlling Cell Interactions with DNA Directed Assembly

K Mathis, CTY Chan, B Meckes - Advanced Healthcare …, 2024 - Wiley Online Library
The creation of complex cellular environments is critical to mimicking tissue environments
that will play a critical role in next‐generation tissue engineering, stem cell programming …

DNA hybridization to control cellular interactions

AL Furst, SH Klass, MB Francis - Trends in biochemical sciences, 2019 - cell.com
A key challenge in many biological studies is the inability to control the placement of cells in
two and three dimensions. As our understanding of the importance of complexity in cellular …

Lipid-DNA conjugates for cell membrane modification, analysis, and regulation

Y Bagheri, F Shafiei, S Chedid, B Zhao… - Supramolecular …, 2019 - Taylor & Francis
Lipids and DNAs are two major building blocks of life. Interestingly, by chemically linking
these two natural compounds together, synthetic lipid-DNA conjugates exhibit several …

[HTML][HTML] Simple, affordable, and modular patterning of cells using DNA

KA Cabral, DM Patterson, OJ Scheideler… - Journal of visualized …, 2021 - ncbi.nlm.nih.gov
The relative positioning of cells is a key feature of the microenvironment that organizes cell-
cell interactions. To study the interactions between cells of the same or different type …