Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

A microglial cell is both a glial cell of the central nervous system and a mononuclear
phagocyte, which belongs to the haematopoietic system and is involved in inflammatory and …

Depending on the species, microglial cells represent 5–20% of glial cells in the adult brain.
As the innate immune effector of the brain, microglia are involved in several functions …

Background: Air pollution is linked to central nervous system disease, but the mechanisms
responsible are poorly understood. Objectives: Here, we sought to address the brain-region …

Cells undergoing apoptosis are efficiently located and engulfed by phagocytes. The
mechanisms by which macrophages, the professional scavenging phagocytes of apoptotic …

Microglia have neuroprotective capacities, yet chronic activation can promote neurotoxic
inflammation. Neuronal fractalkine (FKN), acting on CX3CR1, has been shown to suppress …

Several neurodegenerative disorders are associated with evidence of inflammation, one
feature of which is increased activation of microglia, the most likely cellular source of …

Alzheimer's disease (AD) is the most common form of dementia. The risk of AD increases
with age. Although two of the main pathological features of AD, amyloid plaques and …

No long term effective treatments are currently available for brain neurological disorders
such as stroke/cerebral ischemia, traumatic brain injury and neurodegenerative disorders …

It can be anticipated that a more detailed understanding of neuroinflammatory mechanisms
in Parkinson's disease will lead to new cellular and molecular targets, which may, in turn …