The Notch signaling pathway in skeletal muscle health and disease

D Vargas‐Franco, R Kalra, I Draper, CA Pacak… - Muscle & …, 2022 - Wiley Online Library
The Notch signaling pathway is a key regulator of skeletal muscle development and
regeneration. Over the past decade, the discoveries of three new muscle disease genes …

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

C Wang, R Rabadan Ros, P Martinez-Redondo… - Nature …, 2021 - nature.com
Short-term, systemic expression of the Yamanaka reprogramming factors (Oct-3/4, Sox2,
Klf4 and c-Myc [OSKM]) has been shown to rejuvenate aging cells and promote tissue …

[HTML][HTML] The association between sleep quality and telomere length: A systematic literature review

D Sabot, R Lovegrove, P Stapleton - Brain, Behavior, & Immunity-Health, 2023 - Elsevier
Several sleep parameters present an elevated risk for processes that contribute to cellular
aging. Short sleep duration, sleep apnoea, and insomnia are significantly associated with …

POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling

Y Du, D Li, N Li, C Su, C Yang, C Lin, M Chen… - Cell death & …, 2018 - nature.com
Copy number variations (CNVs) are key drivers of colorectal cancer (CRC). Our previous
studies revealed that protein O-fucosyltransferase 1 (POFUT1) overexpression is driven by …

Furamidine rescues myotonic dystrophy type I associated mis-splicing through multiple mechanisms

JR Jenquin, LA Coonrod, QA Silverglate… - ACS chemical …, 2018 - ACS Publications
Myotonic dystrophy type 1 (DM1) is an autosomal dominant, CTG• CAG microsatellite
expansion disease. Expanded CUG repeat RNA sequester the muscleblind-like (MBNL) …

Therapeutic efficacy of rscAAVrh74. miniCMV. LIPA gene therapy in a mouse model of lysosomal acid lipase deficiency

P Lam, A Ashbrook, DA Zygmunt, C Yan, H Du… - … Therapy-Methods & …, 2022 - cell.com
Lysosomal acid lipase deficiency (LAL-D) presents as one of two rare autosomal recessive
diseases: Wolman disease (WD), a severe disorder presenting in infancy characterized by …

Combination treatment of erythromycin and furamidine provides additive and synergistic rescue of mis-splicing in myotonic dystrophy type 1 models

JR Jenquin, H Yang, RW Huigens III… - ACS pharmacology & …, 2019 - ACS Publications
Myotonic dystrophy type 1 (DM1) is a multisystemic disease that presents with clinical
symptoms including myotonia, cardiac dysfunction, and cognitive impairment. DM1 is …

A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels

K Reddy, JR Jenquin, OL McConnell… - Proceedings of the …, 2019 - National Acad Sciences
A CTG repeat expansion in the DMPK gene is the causative mutation of myotonic dystrophy
type 1 (DM1). Transcription of the expanded CTG repeat produces toxic gain-of-function …

[HTML][HTML] LncRNA 2310043L19Rik inhibits differentiation and promotes proliferation of myoblast by sponging miR-125a-5p

R Li, B Li, M Shen, Y Cao, X Zhang, W Li, J Tao… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Although many long non-coding RNAs (lncRNAs) have been identified in muscle, some of
their physiological functions and regulatory mechanisms remain elusive. Here we report the …

Predicting the pro-longevity or anti-longevity effect of model organism genes with enhanced Gaussian noise augmentation-based contrastive learning on protein …

I Alsaggaf, AA Freitas, C Wan - NAR Genomics and …, 2024 - academic.oup.com
Ageing is a highly complex and important biological process that plays major roles in many
diseases. Therefore, it is essential to better understand the molecular mechanisms of ageing …