Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative
metabolism in mitochondria is the main energy source of the heart, and the inability to …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane
protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum …

Calcium (Ca2+) uptake into the mitochondrial matrix is critically important to cellular function.
As a regulator of matrix Ca2+ levels, this flux influences energy production and can initiate …

FOXP3+ regulatory T cells (Tregs) are central for peripheral tolerance, and their
deregulation is associated with autoimmunity. Dysfunctional autoimmune Tregs display pro …

Calcium is thought to play an important role in regulating mitochondrial function. Evidence
suggests that an increase in mitochondrial calcium can augment ATP production by altering …

This review highlights the biological importance of mitochondrial energy metabolism and the
applications of multiple optical/electrochemical approaches to determine energy …

VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …