The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …

Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Metastasis is a multistep process that culminates in the spread of cells from a primary tumor
to a distant site or organs. For tumor cells to be able to metastasize, they have to locally …

Cancer is the second cause of death in 2015, and it has been estimated to surpass heart
diseases as the leading cause of death in the next few years. Several mechanisms are …

In recent years, numerous in vivo molecular imaging probes have been developed. As a
consequence, much has been published on the design and synthesis of molecular imaging …

In recent decades, dysregulation of proteases and atypical proteolysis have become
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …

The biology of human granzymes remains enigmatic in part due to our inability to probe their
functions outside of in vitro assays or animal models with divergent granzyme species. We …

Tumors are often characterized by hypoxia, vascular abnormalities, low extracellular pH,
increased interstitial fluid pressure, altered choline-phospholipid metabolism, and aerobic …

Proteases in normal cells are important in carrying out biological processes. In living
systems, a balance between proteases and their anti-proteases occur, and disturbance of …

With many desirable properties such as ease of synthesis, small size, lack of
immunogenicity, and versatile chemistry, aptamers represent a class of targeting ligands that …