Heat shock protein 90 as therapeutic target for CVDs and heart ageing

SA Dabravolski, VN Sukhorukov, VA Kalmykov… - International Journal of …, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are the leading cause of death globally, representing
approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart …

Viral infections: negative regulators of apoptosis and oncogenic factors

AV Zamaraev, B Zhivotovsky, GS Kopeina - Biochemistry (Moscow), 2020 - Springer
The disruption of apoptotic cell death process is closely associated with the etiology of
various diseases, including cancer. Permanent viral infections can cause different types of …

What do we need to know and understand about p53 to improve its clinical value?

N Salomao, K Karakostis, T Hupp… - The Journal of …, 2021 - Wiley Online Library
Few proteins are more studied than the p53 tumour suppressor, but what have we learned
from these studies and what do we really know about p53 that can benefit clinical practice …

p90RSK regulates p53 pathway by MDM2 phosphorylation in thyroid tumors

I Maietta, F Del Peschio, P Buonocore, E Viscusi… - Cancers, 2022 - mdpi.com
Simple Summary p90RSK is a downstream effector protein of the MAPK pathway. In many
human cancers, the MAPK pathway is constitutively activated due to oncogenic mutations of …

The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway

K Karakostis, L Malbert-Colas, A Thermou, B Vojtesek… - Molecular Cancer, 2024 - Springer
Background The ATM kinase constitutes a master regulatory hub of DNA damage and
activates the p53 response pathway by phosphorylating the MDM2 protein, which develops …

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM)

L Zhong, P Hao, Q Zhang, T Jiang, H Li, J Xiao, C Li… - Elife, 2022 - elifesciences.org
Multiple myeloma (MM) accounts for~ 10% of all haematologic malignancies. Little is known
about high intratumour heterogeneities in patients stratified by the Revised International …

Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

AI Youssef, GM Khaled, A Amleh - BMC cancer, 2023 - Springer
Background There is considerable evidence that microRNAs (miRNAs) regulate several key
tumor-associated genes/pathways and may themselves have a dual regulatory function …

Comprehensive pan-cancer analysis of senescence with cancer prognosis and immunotherapy

Q Zhao, W Hu, J Xu, S Zeng, X Xi, J Chen… - Frontiers in Molecular …, 2022 - frontiersin.org
Senescence is a double-edged sword in tumorigenesis and affects the immunotherapy
response through the modulation of the host's immune system. However, there is currently a …

[HTML][HTML] Systematic analysis of enhancer regulatory circuit perturbation driven by copy number variations in malignant glioma

J Xiao, X Jin, C Zhang, H Zou, Z Chang, N Han, X Li… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Enhancers are emerging regulatory regions controlling gene expression in
diverse cancer types. However, the functions of enhancer regulatory circuit perturbations …

High glucose treatment limits drosha protein expression and alters AngiomiR maturation in microvascular primary endothelial cells via an mdm2-dependent …

B Lam, E Nwadozi, TL Haas, O Birot, E Roudier - Cells, 2021 - mdpi.com
Diabetes promotes an angiostatic phenotype in the microvascular endothelium of skeletal
muscle and skin. Angiogenesis-related microRNAs (angiomiRs) regulate angiogenesis …