L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an
extensive and complex metabolism along several pathways, resulting in many bioactive …

Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …

Chronic stress disrupts immune homeostasis while gut microbiota-derived metabolites
attenuate inflammation, thus promoting resilience to stress-induced immune and behavioral …

Millions of individuals around the world are afflicted with Parkinson's disease (PD), a
prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, a distinguished …

Impaired kidney function and increased inflammatory process occurring in the course of
Chronic Kidney Disease (CKD) contribute to the development of complex amino-acid …

Accumulating evidence suggests the key role of the kynurenine pathway (KP) of the
tryptophan metabolism in the pathogenesis of several diseases. Despite extensive research …

Flavin-dependent monooxygenases catalyze a wide variety of redox reactions in important
biological processes and are responsible for the synthesis of highly complex natural …

Abstract l-tryptophan, an essential amino acid, regulates protein homeostasis and plays a
role in neurotransmitter-mediated physiological events. It also influences age-associated …

Aortic diseases are the primary public health concern. As asymptomatic diseases,
abdominal aortic aneurysm (AAA) and atherosclerosis are associated with high morbidity …

Abstract Kynurenine‐3‐monooxygenase (KMO) is a mitochondrial enzyme involved in the
eukaryotic kynurenine pathway (KP), which is the major catabolic route of tryptophan. KMO …