Beads bound to a solid support and to nucleic acids

H Koster, DM Lough - US Patent 6,133,436, 2000 - Google Patents
Eckstein, Nucleoside phosphorothioates, Ann. Rev. Bio chem. 54: 367-402 (1985). Eckstein
and Goody, Synthesis and properties of diastere oisomers of adenosine 5'-(O-1 …

DNA diagnostics based on mass spectrometry

H Koster, GS Higgens, DP Little - US Patent 6,043,031, 2000 - Google Patents
The invention provides fast and highly accurate mass spectrometer based processes for
detecting a particular nucleic acid sequence in a biological sample. Depending on the …

DNA diagnostics based on mass spectrometry

H Köster - US Patent 6,268,144, 2001 - Google Patents
Fast and highly accurate mass spectrometry-based processes for detecting particular
nucleic acid molecules and sequences in the molecules are provided. Depending upon the …

DNA sequencing by mass spectrometry via exonuclease degradation

H Koster - US Patent 6,140,053, 2000 - Google Patents
The invention provides fast and highly accurate mass spectrometer based processes for
directly sequencing a target nucleic acid (or fragments generated from the target nucleic …

Mass spectrometers and methods for rapid screening of libraries of different materials

WH Weinberg, EW McFarland, P Cong… - US Patent …, 1999 - Google Patents
This application is a continuation-in-part of commonly assigned US patent application Ser.
No. 08/898,715, filed Jul. 22, 1997, and a continuation-in-part of commonly assigned, co …

Fragmentation-based methods and systems for sequence variation detection and discovery

D Van Den Boom, S Boecker - US Patent 7,820,378, 2010 - Google Patents
US7820378B2 - Fragmentation-based methods and systems for sequence variation detection
and discovery - Google Patents US7820378B2 - Fragmentation-based methods and systems …

DNA sequencing by mass spectrometry

H Köster - US Patent 6,194,144, 2001 - Google Patents
4,948,442 8/1990 Manns................... 156/731 _ _ _ 4,994,373 2/1991 stavrianopoulos et a1_
435/@ The invention describes a neW method to sequence DNA. 5,002,868 3/1991 …

Spinal fusion implant with bone screws

GK Michelson - US Patent 7,935,149, 2011 - Google Patents
An interbody spinal fusion implant made of a material other than bone adapted for
placement across an intervertebral space formed across the height of a disc space between …

DNA diagnostics based on mass spectrometry

H Köster, DP Little, A Braun - US Patent 6,258,538, 2001 - Google Patents
Fu et al., Efficient preparation of short DNA sequence ladders potentially suitable for MALDI-
TOF DNA sequenc ing, Genetic Analysis 12: 137-142 (1996). Fu et al., Sequencing double …

Time-of-flight mass spectrometry analysis of biomolecules

ML Vestal, P Juhasz - US Patent 5,625,184, 1997 - Google Patents
A time-of-flight mass spectrometer for measuring the mass to-charge ratio of a sample
molecule is described. The spectrometer provides independent control of the electric field …