[HTML][HTML] Investigational therapies for ischemic stroke: neuroprotection and neurorecovery

P Sahota, SI Savitz - Neurotherapeutics, 2011 - Elsevier
Stroke is one of the leading causes of death and disability worldwide. Current treatment
strategies for ischemic stroke primarily focus on reducing the size of ischemic damage and …

Progress in stem cell therapy for major human neurological disorders

PL Martínez-Morales, A Revilla, I Ocaña… - Stem Cell Reviews and …, 2013 - Springer
Human neurological disorders such as Alzheimer's disease (AD), Parkinson's disease,
stroke or spinal cord injury are caused by the loss of neurons and glial cells in the brain or …

Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony …

SH Yoon, YS Shim, YH Park, JK Chung, JH Nam… - Stem …, 2007 - academic.oup.com
To assess the safety and therapeutic efficacy of autologous human bone marrow cell (BMC)
transplantation and the administration of granulocyte macrophage-colony stimulating factor …

Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice

J Sanchez-Ramos, S Song, V Sava, B Catlow, X Lin… - Neuroscience, 2009 - Elsevier
Granulocyte colony stimulating factor (G-CSF) is a multi-modal hematopoietic growth factor,
which also has profound effects on the diseased CNS. G-CSF has been shown to enhance …

Anti-apoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat

I Solaroglu, T Tsubokawa, J Cahill, JH Zhang - Neuroscience, 2006 - Elsevier
We investigated the molecular mechanisms of the anti-apoptotic properties of granulocyte-
colony stimulating factor (G-CSF) on neurons and whether G-CSF affects glial cell survival …

Pediatric spinal cord injury: a review

NSC Cunha, A Malvea, S Sadat, GM Ibrahim… - Children, 2023 - mdpi.com
A spinal cord injury (SCI) can be a devastating condition in children, with profound
implications for their overall health and quality of life. In this review, we aim to provide a …

Inhibition of Rho‐kinase protects cerebral barrier from ischaemia‐evoked injury through modulations of endothelial cell oxidative stress and tight junctions

CL Gibson, K Srivastava, N Sprigg… - Journal of …, 2014 - Wiley Online Library
Ischaemic strokes evoke blood–brain barrier (BBB) disruption and oedema formation
through a series of mechanisms involving Rho‐kinase activation. Using an animal model of …

G-CSF attenuates neuroinflammation and stabilizes the blood–brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxia-ischemia in rats

L Li, DW McBride, D Doycheva, BJ Dixon, PR Krafft… - Experimental …, 2015 - Elsevier
Objective Neonatal hypoxia occurs in approximately 60% of premature births and is
associated with a multitude of neurological disorders. While various treatments have been …

Growth factors in ischemic stroke

S Lanfranconi, F Locatelli, S Corti… - Journal of cellular …, 2011 - Wiley Online Library
Background• Search strategies• Haematopoietic growth factors• Granulocyte colony‐
stimulating factor‐G‐CSF and experimental stroke‐G‐CSF and human stroke‐Ongoing …

A novel neuroprotectant granulocyte-colony stimulating factor

I Solaroglu, J Cahill, V Jadhav, JH Zhang - Stroke, 2006 - Am Heart Assoc
Background and Purpose—Granulocyte-colony stimulating factor (G-CSF) is a growth factor
that orchestrates the proliferation, differentiation, and survival of hematopoietic progenitor …