Autonomic Nervous System Dysfunction: JACC Focus Seminar
JJ Goldberger, R Arora, U Buckley… - Journal of the American …, 2019 - jacc.org
Autonomic nervous system control of the heart is a dynamic process in both health and
disease. A multilevel neural network is responsible for control of chronotropy, lusitropy …
disease. A multilevel neural network is responsible for control of chronotropy, lusitropy …
Cardiac pacemaker activity and aging
A progressive decline in maximum heart rate (mHR) is a fundamental aspect of aging in
humans and other mammals. This decrease in mHR is independent of gender, fitness, and …
humans and other mammals. This decrease in mHR is independent of gender, fitness, and …
Transcriptomic profiling of the developing cardiac conduction system at single-cell resolution
Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …
Three‐dimensional integrated functional, structural, and computational mapping to define the structural “fingerprints” of heart‐specific atrial fibrillation drivers in human …
Background Structural remodeling of human atria plays a key role in sustaining atrial
fibrillation (AF), but insufficient quantitative analysis of human atrial structure impedes the …
fibrillation (AF), but insufficient quantitative analysis of human atrial structure impedes the …
High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling
RS Stephenson, A Atkinson, P Kottas, F Perde… - Scientific reports, 2017 - nature.com
Cardiac arrhythmias and conduction disturbances are accompanied by structural
remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction …
remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction …
Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure
The human sinoatrial node (SAN) efficiently maintains heart rhythm even under adverse
conditions. However, the specific mechanisms involved in the human SAN's ability to …
conditions. However, the specific mechanisms involved in the human SAN's ability to …
What makes the sinoatrial node tick? A question not for the faint of heart
L Donald, EG Lakatta - Philosophical Transactions of the …, 2023 - royalsocietypublishing.org
Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …
engaged in an active investigation of when and why the heart would beat. After the …
Pharmacologic approach to sinoatrial node dysfunction
P Mesirca, VV Fedorov, TJ Hund… - Annual review of …, 2021 - annualreviews.org
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
A radiation therapy contouring atlas for cardiac conduction node delineation
P Loap, V Servois, G Dhonneur, K Kirov… - Practical radiation …, 2021 - Elsevier
Purpose The heart is a complex organ at risk. Currently, radiation therapy cardiac
delineation atlases do not include conduction system substructures, which exposure may …
delineation atlases do not include conduction system substructures, which exposure may …
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node
Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and
whether human SAN excitability requires voltage-gated sodium channels (Nav) remains …
whether human SAN excitability requires voltage-gated sodium channels (Nav) remains …