The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Drugs with low water solubility are predisposed to poor and variable oral bioavailability and,
therefore, to variability in clinical response, that might be overcome through an appropriate …

Cyclodextrins (CDs) are enabling pharmaceutical excipients that can be found in numerous
pharmaceutical products worldwide. Because of their favorable toxicologic profiles, CDs are …

Supramolecular chemistry introduces us to the macrocyclic host cyclodextrin, which has a
hydrophobic cavity. The hydrophobic cavity has a higher affinity for hydrophobic guest …

Background: Cyclodextrins (CDs) are versatile excipients with an essential role in drug
delivery, as they can form non-covalently bonded inclusion complexes (host-guest …

Terpenoids are naturally occurring secondary metabolites that consist of isoprene units (ie, 2-
methyl-1, 3-butadiene). Terpenoids became recognized because of their diverse …

Inclusion complexes have various applications in different fields of drug delivery and
pharmaceutical industry due to their ability of complexation with guest molecules and …

Introduction: Poor solubility and dissolution of drugs are the major challenges in drug
formulation and delivery. In order to improve the solubility and dissolution profile of drugs …

Abstract pH-mediated drug-drug interactions (DDI) is a prevalent DDI in drug development,
especially for weak base compounds with highly pH-dependent solubility. FDA has released …

Flavonoids, also known as polyphenols, contain carbonyl and hydroxyl groups and are
capable of forming complexes with metal ions. In this perspective, complexation of curcumin …