How can machine learning and multiscale modeling benefit ocular drug development?

N Wang, Y Zhang, W Wang, Z Ye, H Chen, G Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …

Damaging effects of ultraviolet radiation on the cornea

NC Delic, JG Lyons, N Di Girolamo… - Photochemistry and …, 2017 - Wiley Online Library
The cornea sits at the anterior aspect of the eye and, like the skin, is highly exposed to
ultraviolet radiation (UVR). The cornea blocks a significant proportion of UVB from reaching …

On the shell model for human eye in Glaucoma disease

S Dastjerdi, B Akgöz, Ö Civalek - International Journal of Engineering …, 2021 - Elsevier
A new mechanical and analytical models of the human eye is presented in order to study
Glaucoma disease and its complications. Mechanical modeling of the human eye is …

Characterization of non-linear mechanical behavior of the cornea

A Ashofteh Yazdi, J Melchor, J Torres, I Faris… - Scientific reports, 2020 - nature.com
The objective of this study was to evaluate which hyperelastic model could best describe the
non-linear mechanical behavior of the cornea, in order to characterize the capability of the …

Noninvasive measurement of wave speed of porcine cornea in ex vivo porcine eyes for various intraocular pressures

B Zhou, AJ Sit, X Zhang - Ultrasonics, 2017 - Elsevier
The objective of this study was to extend an ultrasound surface wave elastography (USWE)
technique for noninvasive measurement of ocular tissue elastic properties. In particular, we …

[HTML][HTML] Cataract surgery on post radial keratotomy patients

A Meduri, M Urso, GA Signorino… - International Journal …, 2017 - ncbi.nlm.nih.gov
This study aims to evaluate and to compare three different approaches of cataract surgery to
patients with previous radial keratotomy (RK), and to analyze the mechanical properties of …

Biomechanical simulation of stress concentration and intraocular pressure in corneas subjected to myopic refractive surgical procedures

PJ Shih, IJ Wang, WF Cai, JY Yen - Scientific reports, 2017 - nature.com
Recent advances in the analysis of corneal biomechanical properties remain difficult to
predict the structural stability before and after refractive surgery. In this regard, we applied …

The applications of finite element analysis in proximal humeral fractures

Y Ye, W You, W Zhu, J Cui, K Chen… - … methods in medicine, 2017 - Wiley Online Library
Proximal humeral fractures are common and most challenging, due to the complexity of the
glenohumeral joint, especially in the geriatric population with impacted fractures, that the …

Estimation of scleral mechanical properties from air-puff optical coherence tomography

D Bronte-Ciriza, JS Birkenfeld, A de la Hoz… - Biomedical Optics …, 2021 - opg.optica.org
We introduce a method to estimate the biomechanical properties of the porcine sclera in
intact eye globes ex vivo, using optical coherence tomography that is coupled with an air …

Development and challenges in finite element modelling of post-installed anchors in concrete

CC Neupane, J Lee, T Pokharel… - Structure and …, 2023 - Taylor & Francis
Finite element analysis (FEA) has been used as a successful supplement to experimental
testing in various studies for simulation of anchorage behaviour. Throughout the years …