The retinoid X receptors and their ligands

MI Dawson, Z Xia - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
This chapter presents an overview of the current status of studies on the structural and
molecular biology of the retinoid X receptor subtypes α, β, and γ (RXRs, NR2B1–3), their …

Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables

S Das, WK Ng, P Kanaujia, S Kim, RBH Tan - Colloids and surfaces b …, 2011 - Elsevier
This study aimed to prepare solid lipid nanoparticles (SLNs) of a hydrophobic drug, tretinoin,
by emulsification–ultrasonication method. Solubility of tretinoin in the solid lipids was …

Natural and structure-based RXR ligand scaffolds and their functions

M Dominguez, S Alvarez… - Current topics in medicinal …, 2017 - ingentaconnect.com
Retinoid X receptors (RXRs) are promiscuous partners of heterodimeric associations with
other members of the Nuclear Receptor (NR) superfamily. Through these liaisons RXR …

Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in …

O Afonja, D Juste, S Das, S Matsuhashi, HH Samuels - Oncogene, 2004 - nature.com
The growth of human breast tumor cells is regulated through signaling involving cell surface
growth factor receptors and nuclear receptors of the steroid/thyroid/retinoid receptor gene …

Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders

SJ Lim, MK Lee, CK Kim - Journal of controlled release, 2004 - Elsevier
The principal aim of this study was to investigate whether the solid lipid nanoparticle (SLN)
powder formulation of all-trans retinoic acid (ATRA) can favorably alter the chemical stability …

Preparation of all-trans retinoic acid nanosuspensions using a modified precipitation method

X Zhang, Q Xia, N Gu - Drug development and industrial pharmacy, 2006 - Taylor & Francis
ABSTRACT All-Trans Retinoic Acid (ATRA) nanosuspensions were prepared with a
modified precipitation method. The ATRA solution in acetone was injected into pure water by …

Delivery of retinoic acid to LNCap human prostate cancer cells using solid lipid nanoparticles

MH Akanda, R Rai, IJ Slipper, BZ Chowdhry… - International journal of …, 2015 - Elsevier
In this study retinoic acid (RTA) loaded solid lipid nanoparticles (SLNs) were optimized by
tuning the process parameters (pressure/temperature) and using different lipids to develop …

A novel hybrid delivery system: polymer-oil nanostructured carrier for controlled delivery of highly lipophilic drug all-trans-retinoic acid (ATRA)

M Narvekar, HY Xue, HL Wong - International journal of pharmaceutics, 2012 - Elsevier
Many recently developed drugs encounter delivery issues due to their high lipophilicity and
poor aqueous solubility. This study reports the development of a novel hybrid nanocarrier …

PPARγ and RXRγ ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models

A Papi, L Tatenhorst, D Terwel… - Journal of …, 2009 - Wiley Online Library
Glioblastoma represent the most common primary brain tumor in adults and are currently
considered incurable. We investigated antiproliferative and anti‐invasive mechanisms of 6 …

FT-IR-and Raman-based biochemical profiling of the early stage of pulmonary metastasis of breast cancer in mice

K Chrabaszcz, K Kochan, A Fedorowicz, A Jasztal… - Analyst, 2018 - pubs.rsc.org
The combination of FT-IR and Raman spectroscopies allowed the biochemical profiling of
lungs in the early stage of pulmonary metastasis in the murine model of breast cancer …