The cellular response to DNA damage (DDR) that causes replication collapse and/or DNA
double strand breaks, is characterised by a massive change in the post-translational …

The search for new therapeutic targets and their implications in drug development remains
an emerging scientific topic. BRCT-bearing proteins are found in Archaea, Bacteria …

The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1 and
RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non …

In mitosis, cells inactivate DNA double-strand break (DSB) repair pathways to preserve
genome stability. However, some early signaling events still occur, such as recruitment of …

Induction of DNA double-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is
associated with ATM-dependent repression of ribosomal RNA synthesis and large-scale …

XRCC1 accelerates repair of DNA single-strand breaks by acting as a scaffold protein for the
recruitment of Polβ, LigIIIα, and end-processing factors, such as PNKP and APTX. XRCC1 …

Bloom's syndrome is caused by inactivation of the BLM helicase, which functions with
TOP3A and RMI1-2 (BTR complex) to dissolve recombination intermediates and avoid …

Abstract TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA
replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation …

The Bloom syndrome complex is a DNA damage repair machine. It consists of several
protein components which are functional in isolation, but interdependent in cells for the …

Coordination of the cellular response to DNA damage is organised by multi-domain
'scaffold'proteins, including 53BP1 and TOPBP1, which recognise post-translational …