Functional characterization of a protein is often facilitated by its 3D structure. However, the
fraction of experimentally known 3D models is currently less than 1% due to the inherently …

The ability to engineer the precise geometries, fine-tuned energetics and subtle dynamics
that are characteristic of functional proteins is a major unsolved challenge in the field of …

Loops are the most variable regions of protein structure and are, in general, the least
accurately predicted. Their prediction has been approached in two ways, ab initio and …

Protein loops are often involved in important biological functions such as molecular
recognition, signal transduction, or enzymatic action. The three dimensional structures of …

The FALC-Loop web server provides an online interface for protein loop modeling by
employing an ab initio loop modeling method called FALC (fragment assembly and …

SuperLooper provides the first online interface for the automatic, quick and interactive
search and placement of loops in proteins (LIP). A database containing half a billion …

Background Template-target sequence alignment and loop modeling are key components of
protein comparative modeling. Short loops can be predicted with high accuracy using …

Sampling errors are very common in super long loop (referring here to loops that have more
than thirteen residues) prediction, simply because the sampling space is vast. We have …

Protein modeling has been a very challenging problem in drug discovery and computational
biology. The latest advances and progress in computational power have helped to solve this …

Abstract SuperLooper2 (SL2)(http://proteinformatics. charite. de/sl2) is the updated version
of our previous web-server SuperLooper, a fragment based tool for the prediction and …