Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

Introduction: Glucocorticoids represent the standard therapy for reducing inflammation and
immune activation in various diseases. However, as with any potent medication, they are not …

Imbalance between the activities of pro-inflammatory M1 and anti-inflammatory M2
macrophages in rheumatoid arthritis (RA) induces synovial inflammation and autoimmunity …

Nano-formulating dexamethasone, and administering it via intravenous injection or
inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent …

Abstract Background Glucocorticoids (GCs) show powerful treatment effect on rheumatoid
arthritis (RA). However, the clinical application is limited by their nonspecific distribution after …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease associated with
persistent multiarticular synovitis, cartilage destruction, and even loss of joint function …

The transcription factor NF-kB plays a pivotal role in the pathogenesis of rheumatoid arthritis.
Here we attempt to slow arthritis progression by co-delivering the glucocorticoid …

Glucocorticoid (GC) is the cornerstone therapy of rheumatoid arthritis, but high doses are
associated with serious adverse effects. In an effort to improve the efficacy of low-dose GC …

Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that
exacerbate the pathogenesis of rheumatoid arthritis (RA). Here we show that~ 40 nm …

In the absence of timely and proper treatments, injuries to articular cartilage (AC) can lead to
cartilage degeneration and ultimately result in osteoarthritis. Regenerative medicine and …