[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

CL Wainwright, MM Teixeira, DL Adelson… - Pharmacological …, 2022 - Elsevier
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …

Cannabis and its constituents for cancer: History, biogenesis, chemistry and pharmacological activities

S Lal, A Shekher, AS Narula, H Abrahamse… - Pharmacological …, 2021 - Elsevier
Cannabis has long been used for healing and recreation in several regions of the world.
Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been …

Tailored biosensors for drug screening, efficacy assessment, and toxicity evaluation

Y Tao, L Chen, M Pan, F Zhu, D Zhu - ACS sensors, 2021 - ACS Publications
Biosensors have been flourishing in the field of drug discovery with pronounced
developments in the past few years. They facilitate the screening and discovery of innovative …

An emerging paradigm to develop analytical methods based on immobilized transmembrane proteins and its applications in drug discovery

Q Li, G Yin, J Wang, L Li, Q Liang, X Zhao… - TrAC Trends in …, 2022 - Elsevier
The way to immobilize a protein onto a solid surface is the cornerstone for developing many
bioanalytical assays which are applied in protein functional assay, protein-ligand interaction …

Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays

F Xu, T Hou, A Shen, H Jin, Y Xiao, W Yu, X Li… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Traditional Chinese medicine (TCM) has a long
history in the prevention and treatment of pandemics. The TCM formula Lung Cleansing and …

CPA4 promotes EMT in pancreatic cancer via stimulating PI3K-AKT-mTOR signaling

Q Shao, Z Zhang, R Cao, H Zang, W Pei… - OncoTargets and …, 2020 - Taylor & Francis
Background Carboxypeptidase A4 (CPA4), as a novel tumor biomarker, is prevalently
observed in various cancers. However, the potential role of CPA4 in pancreatic cancer (PC) …

Cannabis as a potent therapeutic agent for pharmaceutical drugs: Recent advancement in drug discovery and human healthcare

D Sharma, S Bhushan, DC Agrawal, MK Dhar… - Cannabis/Marijuana for …, 2022 - Springer
Cannabis has been well known for centuries due to its medicinal properties. In recent
decades, the inclination of researchers towards its important phytoconstituents as a potential …

Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia

H Zhou, T Hou, A Shen, W Yu, L Zhou, W Yuan… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Prostatitis and benign prostatic hyperplasia (BPH) are
inflammations of the prostate gland, which surrounds the urethra in males. Jinqiancao …

[HTML][HTML] Cannabinoid receptors type 2: Function and Development in Agonist Discovery from synthetic and natural sources with Applications for the Therapy of …

S Hu, G Cheng, G Chen, H Zhou, Q Zhang… - Arabian Journal of …, 2023 - Elsevier
Abstract Type-2 cannabinoid receptor (CB2R) is a member of the G protein-coupled receptor
superfamily with various biological activities in pain regulation, anti-inflammation, anti …

The dual-targeting mechanism of an anti-inflammatory diarylheptanoid from Curcuma zedoaria (Christm.) Roscoe with the capacity for β2-adrenoreceptor agonism …

X Chen, H Zhou, T Hou, J Lu, J Wang, L Zhou… - Chemico-Biological …, 2023 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease
characterized by symptoms of shortness of breath and chronic inflammation. Curcuma …