[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …
Cannabis and its constituents for cancer: History, biogenesis, chemistry and pharmacological activities
S Lal, A Shekher, AS Narula, H Abrahamse… - Pharmacological …, 2021 - Elsevier
Cannabis has long been used for healing and recreation in several regions of the world.
Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been …
Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been …
Tailored biosensors for drug screening, efficacy assessment, and toxicity evaluation
Y Tao, L Chen, M Pan, F Zhu, D Zhu - ACS sensors, 2021 - ACS Publications
Biosensors have been flourishing in the field of drug discovery with pronounced
developments in the past few years. They facilitate the screening and discovery of innovative …
developments in the past few years. They facilitate the screening and discovery of innovative …
An emerging paradigm to develop analytical methods based on immobilized transmembrane proteins and its applications in drug discovery
The way to immobilize a protein onto a solid surface is the cornerstone for developing many
bioanalytical assays which are applied in protein functional assay, protein-ligand interaction …
bioanalytical assays which are applied in protein functional assay, protein-ligand interaction …
Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays
F Xu, T Hou, A Shen, H Jin, Y Xiao, W Yu, X Li… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Traditional Chinese medicine (TCM) has a long
history in the prevention and treatment of pandemics. The TCM formula Lung Cleansing and …
history in the prevention and treatment of pandemics. The TCM formula Lung Cleansing and …
CPA4 promotes EMT in pancreatic cancer via stimulating PI3K-AKT-mTOR signaling
Q Shao, Z Zhang, R Cao, H Zang, W Pei… - OncoTargets and …, 2020 - Taylor & Francis
Background Carboxypeptidase A4 (CPA4), as a novel tumor biomarker, is prevalently
observed in various cancers. However, the potential role of CPA4 in pancreatic cancer (PC) …
observed in various cancers. However, the potential role of CPA4 in pancreatic cancer (PC) …
Cannabis as a potent therapeutic agent for pharmaceutical drugs: Recent advancement in drug discovery and human healthcare
Cannabis has been well known for centuries due to its medicinal properties. In recent
decades, the inclination of researchers towards its important phytoconstituents as a potential …
decades, the inclination of researchers towards its important phytoconstituents as a potential …
Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
H Zhou, T Hou, A Shen, W Yu, L Zhou, W Yuan… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Prostatitis and benign prostatic hyperplasia (BPH) are
inflammations of the prostate gland, which surrounds the urethra in males. Jinqiancao …
inflammations of the prostate gland, which surrounds the urethra in males. Jinqiancao …
[HTML][HTML] Cannabinoid receptors type 2: Function and Development in Agonist Discovery from synthetic and natural sources with Applications for the Therapy of …
S Hu, G Cheng, G Chen, H Zhou, Q Zhang… - Arabian Journal of …, 2023 - Elsevier
Abstract Type-2 cannabinoid receptor (CB2R) is a member of the G protein-coupled receptor
superfamily with various biological activities in pain regulation, anti-inflammation, anti …
superfamily with various biological activities in pain regulation, anti-inflammation, anti …
The dual-targeting mechanism of an anti-inflammatory diarylheptanoid from Curcuma zedoaria (Christm.) Roscoe with the capacity for β2-adrenoreceptor agonism …
X Chen, H Zhou, T Hou, J Lu, J Wang, L Zhou… - Chemico-Biological …, 2023 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease
characterized by symptoms of shortness of breath and chronic inflammation. Curcuma …
characterized by symptoms of shortness of breath and chronic inflammation. Curcuma …