The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
M Tarsounas, P Sung - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …
double-strand break (DSB) repair by homologous recombination and protects DNA …
DNA repair, genome stability and cancer: a historical perspective
PA Jeggo, LH Pearl, AM Carr - Nature Reviews Cancer, 2016 - nature.com
The multistep process of cancer progresses over many years. The prevention of mutations
by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance …
by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance …
Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation
Q Hu, MV Botuyan, D Zhao, G Cui, E Mer, G Mer - Nature, 2021 - nature.com
The BRCA1–BARD1 tumour suppressor is an E3 ubiquitin ligase necessary for the repair of
DNA double-strand breaks by homologous recombination,,,,,,,,–. The BRCA1–BARD1 …
DNA double-strand breaks by homologous recombination,,,,,,,,–. The BRCA1–BARD1 …
A protein interaction landscape of breast cancer
INTRODUCTION Advances in DNA sequencing technology have enabled the widespread
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …
Autophagy in malignant transformation and cancer progression
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …
such a homeostatic activity constitutes a robust barrier against malignant transformation …
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins
Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …
breaks in mammalian cells, the defining step of which is homologous strand exchange …
BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing
The tumour suppressor complex BRCA1–BARD1 functions in the repair of DNA double-
stranded breaks by homologous recombination. During this process, BRCA1–BARD1 …
stranded breaks by homologous recombination. During this process, BRCA1–BARD1 …
Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells
Mutations in the BRCA2 gene are associated with sporadic and familial cancer, cause
genomic instability and sensitize cancer cells to inhibition by the poly (ADP-ribose) …
genomic instability and sensitize cancer cells to inhibition by the poly (ADP-ribose) …
Clinical BRCA1/2 Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance
Reversion mutations in BRCA1 or BRCA2 are associated with resistance to PARP inhibitors
and platinum. To better understand the nature of these mutations, we collated, codified, and …
and platinum. To better understand the nature of these mutations, we collated, codified, and …
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
LR Ferguson, H Chen, AR Collins, M Connell… - Seminars in cancer …, 2015 - Elsevier
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …
prognosis of the affected patient. Genomic instability arises from many different pathways …