As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson's
disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α …

Quantifying how the cellular composition of brain regions vary across development, aging,
sex, and disease, is crucial in experimental neuroscience, and the accuracy of different …

Background Emerging evidence indicates that nod-like receptor family, pyrin domain-
containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in the …

The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here,
we have investigated the role of peripheral inflammation induced by systemic …

Parkinson's disease (PD) is a chronic motor disorder, characterized by progressive loss of
dopaminergic neurons. Numerous studies suggest that glucagon-like peptide-1 (GLP-1) …

Unbiased estimates of neuron numbers within substantia nigra are crucial for experimental
Parkinson's disease models and gene‐function studies. Unbiased stereological counting …

Parkinson's disease (PD) is a chronic, progressive neurodegenerative condition;
characterized with the degeneration of the nigrostriatal dopaminergic pathway and …

Background: Preclinical rodent models for Parkinson's disease (PD) based on viral human
alpha-synuclein (h-αSyn) overexpression recapitulate some of the pathological hallmarks as …

Background Microglial function is vital for maintaining the health of the brain, and their
activation is an essential component of neurodegeneration. There is significant research on …